Natural selection has shaped the strategies for survival and growth of microorganisms. The
success of microorganisms depends not only on slow evolutionary tuning but also on the …

The operation of the central metabolism is typically assumed to be deterministic, but
dynamics and high connectivity of the metabolic network make it potentially prone to …

Scenarios have become a powerful tool in integrated assessment and policy analysis for
climate change. Socio-economic and climate scenarios are often combined to assess …

Often, in living cells different molecular species compete for binding to the same molecular
target. Typical examples are the competition of genes for the transcription machinery or the …

We show theoretically and experimentally a mechanism behind the emergence of wide or
bimodal protein distributions in biochemical networks with nonlinear input–output …

One of the challenging tasks in systems biology is to understand how molecular networks
give rise to emergent functionality and whether universal design principles apply to …

Individual cells respond very differently to changes in environmental conditions.
Stochasticity causes cells to respond at different times, magnitudes or both. Here we …

This paper studies an infinite-server queue in a random environment, meaning that the
arrival rate, the service requirements, and the server work rate are modulated by a general …

Metabolites have to diffuse within the sub-cellular compartments they occupy to specific
locations where enzymes are, so reactions could occur. Conventional flux balance analysis …

In growing cells, protein synthesis and cell growth are typically not synchronous, and, thus,
protein concentrations vary over the cell division cycle. We have developed a theoretical …