Post-stroke depression: mechanisms and pharmacological treatment

RF Villa, F Ferrari, A Moretti - Pharmacology & therapeutics, 2018 - Elsevier
Depression, the most frequent psychiatric disorder following ischaemic stroke, negatively
affects survivals' functional outcome, response to rehabilitation and quality of life …

[HTML][HTML] Behavioral tests in rodent models of stroke

J Ruan, Y Yao - Brain hemorrhages, 2020 - Elsevier
Rodents are the most widely used experimental animals in stroke research due to their
similar vascular anatomy, high reproductive rates, and availability of transgenic models …

Behavioral outcome measures to improve experimental stroke research

MG Balkaya, RC Trueman, J Boltze, D Corbett… - Behavioural brain …, 2018 - Elsevier
Functional recovery after an experimental stroke can be assessed by multiple behavioral
tests, however, there is no consensus about which test to use in long-term stroke recovery …

Mechanisms and therapeutic targets of depression after intracerebral hemorrhage

Y Wu, L Wang, K Hu, C Yu, Y Zhu, S Zhang… - Frontiers in …, 2018 - frontiersin.org
The relationship between depression and intracerebral hemorrhage (ICH) is complicated.
One of the most common neuropsychiatric comorbidities of hemorrhagic stroke is Post-ICH …

Optimizing functional outcome endpoints for stroke recovery studies

M Balkaya, S Cho - Journal of Cerebral Blood Flow & …, 2019 - journals.sagepub.com
Novel therapeutic intervention that aims to enhance the endogenous recovery potential of
the brain during the subacute phase of stroke has produced promising results. The …

Depression of pyroptosis by inhibiting caspase-1 activation improves neurological outcomes of kernicterus model rats

S Li, H Huang, Q Wei, C He, J Feng… - ACS Chemical …, 2021 - ACS Publications
Kernicterus is a severe complication of extreme neonatal hyperbilirubinemia. Prolonged
exposure to high-level unconjugated bilirubin (UCB) directly damages brain tissue …

Combined use of spatial restraint stress and middle cerebral artery occlusion is a novel model of post-stroke depression in mice

G Zhang, L Chen, L Yang, X Hua, B Zhou, Z Miao… - Scientific reports, 2015 - nature.com
Post stroke depression (PSD) is one of the most common complications of ischemic stroke.
At present, the underlying mechanisms are unclear, largely because there are no reliable …

Indoleamine 2, 3‐dioxygenase‐dependent neurotoxic kynurenine metabolism contributes to poststroke depression induced in mice by ischemic stroke along with …

YS Koo, H Kim, JH Park, MJ Kim, YI Shin… - Oxidative Medicine …, 2018 - Wiley Online Library
Aim. Poststroke depression (PSD), which occurs in approximately one‐third of stroke
survivors, is clinically important because of its association with slow functional recovery and …

Buyang huanwu decoction ameliorates poststroke depression via promoting neurotrophic pathway mediated neuroprotection and neurogenesis

L Luo, S Deng, J Yi, S Zhou, Y She… - … and Alternative Medicine, 2017 - Wiley Online Library
Objective. The aim of the present research is to investigate the therapeutic effect of Buyang
Huanwu Decoction (BHD) in poststroke depression (PSD) animal model and illustrate its …

Anti-depressant effects of phosphodiesterase 3 inhibitor cilostazol in chronic mild stress-treated mice after ischemic stroke

YR Kim, HN Kim, KW Hong, HK Shin, BT Choi - Psychopharmacology, 2016 - Springer
Abstract Rationale Phosphodiesterase 3 (PDE3) inhibitor cilostazol ameliorates negative
effects of cerebral hypoperfusion against cerebral ischemic injury through the …