NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
P Paoletti, C Bellone, Q Zhou - Nature Reviews Neuroscience, 2013 - nature.com
NMDA receptors (NMDARs) are glutamate-gated ion channels and are crucial for neuronal
communication. NMDARs form tetrameric complexes that consist of several homologous …
communication. NMDARs form tetrameric complexes that consist of several homologous …
Mechanisms of NMDA receptor regulation
L Mony, P Paoletti - Current opinion in neurobiology, 2023 - Elsevier
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …
expressed in the central nervous system that play key role in brain development and …
Synaptic proximity enables NMDAR signalling to promote brain metastasis
Metastasis—the disseminated growth of tumours in distant organs—underlies cancer
mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and …
mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and …
Regulation of NMDA receptor trafficking by amyloid-β
EM Snyder, Y Nong, CG Almeida, S Paul, T Moran… - Nature …, 2005 - nature.com
Amyloid-β peptide is elevated in the brains of patients with Alzheimer disease and is
believed to be causative in the disease process. Amyloid-β reduces glutamatergic …
believed to be causative in the disease process. Amyloid-β reduces glutamatergic …
Regulation of NMDA glutamate receptor functions by the GluN2 subunits
The N‐methyl‐D‐aspartate receptors (NMDARs) are ionotropic glutamate receptors that
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …
Regulation of NMDA receptors by phosphorylation
BS Chen, KW Roche - Neuropharmacology, 2007 - Elsevier
N-Methyl-d-aspartate (NMDA) receptors are critical for neuronal development and synaptic
plasticity. The molecular mechanisms underlying the synaptic localization and functional …
plasticity. The molecular mechanisms underlying the synaptic localization and functional …
The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2
The NMDA receptor (NMDAR) is a component of excitatory synapses and a key participant
in synaptic plasticity. We investigated the role of two domains in the C terminus of the NR2B …
in synaptic plasticity. We investigated the role of two domains in the C terminus of the NR2B …
Glutamate receptor dynamics in dendritic microdomains
TM Newpher, MD Ehlers - Neuron, 2008 - cell.com
Among diverse factors regulating excitatory synaptic transmission, the abundance of
postsynaptic glutamate receptors figures prominently in molecular memory and learning …
postsynaptic glutamate receptors figures prominently in molecular memory and learning …
Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand
HJ Chung, YH Huang, LF Lau… - Journal of …, 2004 - Soc Neuroscience
Interactions between NMDA receptors (NMDARs) and the PDZ [postsynaptic density-95
(PSD-95)/Discs large/zona occludens-1] domains of PSD-95/SAP90 (synapse-associated …
(PSD-95)/Discs large/zona occludens-1] domains of PSD-95/SAP90 (synapse-associated …
Organelles and trafficking machinery for postsynaptic plasticity
MJ Kennedy, MD Ehlers - Annu. Rev. Neurosci., 2006 - annualreviews.org
Neurons are among the largest and most complex cells in the body. Their immense size and
intricate geometry pose many unique cell-biological problems. How is dendritic architecture …
intricate geometry pose many unique cell-biological problems. How is dendritic architecture …