Liquid chromatography coupled to atmospheric pressure ionization tandem mass
spectrometry is currently the method of choice for the quantitative determination of drugs in …

LC–MS is becoming a standard for many applications, thanks to high sensitivity and
selectivity; nevertheless, some issues are still present, particularly due to matrix effect (ME) …

HIV resides within anatomical 'sanctuary sites', where local drug exposure and viral
dynamics may differ significantly from the systemic compartment. Suboptimal anti-retroviral …

Nirmatrelvir is an antiviral agent active against SARS-CoV-2, the virus causing the pandemic
disease COVID-19. It is administrated in combination with the protease inhibitor ritonavir …

Lopinavir and ritonavir are co-formulated in Kaletra® approved for the treatment of human
immunodeficiency virus infection. A validated analytical method is mandatory for clinical …

Blood and plasma are the biomatrices traditionally used for drug monitoring and their
pharmacokinetic profiling. Blood is the circulating fluid in contact with all organs and tissues …

The determination of the concentrations of antiretroviral drugs in hair is believed to be an
important means for the assessment of the long-term adherence to highly active …

The use of saliva for measuring xenobiotic concentrations has been practiced for a number
of years. While the use of saliva has been generally reserved for the analysis of diagnostic …

A combined assay for the determination of paclitaxel, docetaxel and ritonavir in human
plasma is described. The drugs were extracted from 200μL human plasma using liquid …

Objectives Therapy failure caused by complex population-drug-drug (PDDI) interactions
including CYP3A4 can be predicted using mechanistic physiologically-based …