The repertoire of proteins and nucleic acids in the living world is determined by evolution;
their properties are determined by the laws of physics and chemistry. Explanations of these …

Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …

The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …

Antimalarial chemotherapy, globally reliant on artemisinin-based combination therapies
(ACTs), is threatened by the spread of drug resistance in Plasmodium falciparum parasites …

The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium
falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors …

Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …

Conspectus Over the last century, malaria deaths have decreased by more than 85%.
Nonetheless, there were 405 000 deaths in 2018, mostly resulting from Plasmodium …

Intensified treatment and control efforts since the early 2000s have dramatically reduced the
burden of Plasmodium falciparum malaria. However, drug resistance threatens to derail this …

For more than two decades, chloroquine (CQ) was largely and deliberately used as first
choice drug for malaria treatment. However, worldwide increasing cases of resistant strains …

Malaria afflicts over 200 million people worldwide, and its most lethal etiologic agent,
Plasmodium falciparum, is evolving to resist even the latest-generation therapeutics …