Hyperpolarized 13C MRI: A novel approach for probing cerebral metabolism in health and neurological disease

JT Grist, JJ Miller, F Zaccagna… - Journal of Cerebral …, 2020 - journals.sagepub.com
Cerebral metabolism is tightly regulated and fundamental for healthy neurological function.
There is increasing evidence that alterations in this metabolism may be a precursor and …

Fluorine-containing inhalation anesthetics: chemistry, properties and pharmacology

Y Wang, XX Ming, CP Zhang - Current Medicinal Chemistry, 2020 - ingentaconnect.com
Studies on fluorinated inhalation anesthetics, including synthesis, physical chemistry and
pharmacology, have been summarized in this review. Retrospecting the history of inhalation …

[HTML][HTML] 13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI

JJ Miller, JT Grist, S Serres, JR Larkin, AZ Lau, K Ray… - Scientific reports, 2018 - nature.com
Abstract Hyperpolarised MRI with Dynamic Nuclear Polarisation overcomes the fundamental
thermodynamic limitations of conventional magnetic resonance, and is translating to human …

Cardiac applications of hyperpolarised magnetic resonance

KN Timm, JJ Miller, JA Henry, DJ Tyler - Progress in nuclear magnetic …, 2018 - Elsevier
Cardiovascular disease is the leading cause of death world-wide. It is increasingly
recognised that cardiac pathologies show, or may even be caused by, changes in …

A spin-thermodynamic approach to characterize spin dynamics in TEMPO-based samples for dissolution DNP at 7 T field

F Jähnig, A Himmler, G Kwiatkowski, A Däpp… - Journal of Magnetic …, 2019 - Elsevier
The spin dynamics of dissolution DNP samples consisting of 4.5 M [13 C] urea in a mixture
of (1/1) Vol glycerol/water using 4-Oxo-TEMPO as a radical was investigated. We analyzed …

[PDF][PDF] 心脏右向左分流对偏头痛患者临床症状的影响

凌演演, 王敏, 潘旭东, 赵洪芹, 曲红梅 - 现代生物医学进展, 2020 - biomed.cnjournals.com
摘要目的: 探讨心脏右向左分流(RLS) 对偏头痛患者临床特征是否存在影响, 并研究RLS
分级与头痛强度之间的关系. 方法: 选择2016 年6 月-2018 年12 月青岛大学附属医院收治的偏 …

Technical considerations of MRI methods for validating DNP probes in small animals

CE Harrison, J Chen, SH Lin, JM Park - Advances in Magnetic Resonance …, 2024 - Elsevier
Probes that are developed for dissolution dynamic nuclear polarization (DNP) should meet
numerous requirements such as solubility, glassing, and spin-lattice relation time, yet only a …

Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS

KN Timm, A Apps, JJ Miller, V Ball… - NMR in …, 2018 - Wiley Online Library
Hyperpolarized [1‐13C] pyruvate MRS can measure cardiac pyruvate dehydrogenase
(PDH) flux in vivo through 13C‐label incorporation into bicarbonate. Using this technology …

[PDF][PDF] 超快通道麻醉联合BIS 监测对心脏手术患者的效果及安全性

吴仲烨, 李玲霞, 路喻清, 李艳… - Progress in Modern …, 2020 - biomed.cnjournals.com
摘要目的: 探究超快通道麻醉辅助脑电双频指数(Bispectral index, BIS) 监测对行心脏手术患者
认知功能障碍的影响和安全性. 方法: 选取2014 年1 月-2017 年1 月于我院进行心脏手术的59 …

Quantitative myocardial first‐pass perfusion imaging of CO2‐induced vasodilation in rats

G Kwiatkowski, S Kozerke - NMR in Biomedicine, 2021 - Wiley Online Library
Inducible hypercapnia is an alternative for increasing the coronary blood flow necessary to
facilitate the quantification of myocardial blood flow during hyperemia. The current study …