[HTML][HTML] In vitro models for human malaria: targeting the liver stage

AL Valenciano, MG Gomez-Lorenzo… - Trends in …, 2022 - cell.com
The Plasmodium liver stage represents a vulnerable therapeutic target to prevent disease
progression as the parasite resides in the liver before clinical representation caused by …

Plasmodium vivax Latent Liver Stage Infection and Relapse: Biological Insights and New Experimental Tools

C Schäfer, G Zanghi, AM Vaughan… - Annual Review of …, 2021 - annualreviews.org
Plasmodium vivax is the most widespread human malaria parasite, in part because it can
form latent liver stages known as hypnozoites after transmission by female anopheline …

[HTML][HTML] Recent advances in the development of biosensors for malaria diagnosis

FD Krampa, Y Aniweh, P Kanyong, GA Awandare - Sensors, 2020 - mdpi.com
The impact of malaria on global health has continually prompted the need to develop more
effective diagnostic strategies that could overcome deficiencies in accurate and early …

[HTML][HTML] Same, same but different: Exploring Plasmodium cell division during liver stage development

M Roques, A Bindschedler, R Beyeler… - PLoS …, 2023 - journals.plos.org
Plasmodium parasites have a complex life cycle alternating between a mosquito and a
vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium …

[HTML][HTML] Systems biology of malaria explored with nonhuman primates

MR Galinski - Malaria journal, 2022 - Springer
Abstract “The Primate Malarias” book has been a uniquely important resource for multiple
generations of scientists, since its debut in 1971, and remains pertinent to the present day …

[HTML][HTML] Plasmodium vivax latent liver infection is characterized by persistent hypnozoites, hypnozoite-derived schizonts, and time-dependent efficacy of primaquine

EL Flannery, N Kangwanrangsan, V Chuenchob… - … Therapy-Methods & …, 2022 - cell.com
Plasmodium vivax is a malaria-causing pathogen that establishes a dormant form in the liver
(the hypnozoite), which can activate weeks, months, or years after the primary infection to …

[HTML][HTML] Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets

AA Ruberto, SP Maher, A Vantaux… - Frontiers in Cellular …, 2022 - frontiersin.org
The resilience of Plasmodium vivax, the most widely-distributed malaria-causing parasite in
humans, is attributed to its ability to produce dormant liver forms known as hypnozoites …

[HTML][HTML] A dual fluorescent Plasmodium cynomolgi reporter line reveals in vitro malaria hypnozoite reactivation

AM Voorberg-van Der Wel, AM Zeeman… - Communications …, 2020 - nature.com
Plasmodium vivax malaria is characterized by repeated episodes of blood stage infection
(relapses) resulting from activation of dormant stages in the liver, so-called hypnozoites …

[HTML][HTML] Epigenetically regulated RNA-binding proteins signify malaria hypnozoite dormancy

CG Toenhake, A Voorberg-van der Wel, H Wu… - Cell Reports, 2023 - cell.com
Dormancy enables relapsing malaria parasites, such as Plasmodium vivax and cynomolgi,
to survive unfavorable conditions. It is enabled by hypnozoites, parasites remaining …

[HTML][HTML] Plasmodium 6-Cysteine Proteins: Functional Diversity, Transmission-Blocking Antibodies and Structural Scaffolds

FMT Lyons, M Gabriela, WH Tham… - Frontiers in Cellular and …, 2022 - frontiersin.org
The 6-cysteine protein family is one of the most abundant surface antigens that are
expressed throughout the Plasmodium falciparum life cycle. Many members of the 6 …