[HTML][HTML] In vitro models for human malaria: targeting the liver stage
AL Valenciano, MG Gomez-Lorenzo… - Trends in …, 2022 - cell.com
The Plasmodium liver stage represents a vulnerable therapeutic target to prevent disease
progression as the parasite resides in the liver before clinical representation caused by …
progression as the parasite resides in the liver before clinical representation caused by …
Plasmodium vivax Latent Liver Stage Infection and Relapse: Biological Insights and New Experimental Tools
Plasmodium vivax is the most widespread human malaria parasite, in part because it can
form latent liver stages known as hypnozoites after transmission by female anopheline …
form latent liver stages known as hypnozoites after transmission by female anopheline …
[HTML][HTML] Recent advances in the development of biosensors for malaria diagnosis
The impact of malaria on global health has continually prompted the need to develop more
effective diagnostic strategies that could overcome deficiencies in accurate and early …
effective diagnostic strategies that could overcome deficiencies in accurate and early …
[HTML][HTML] Same, same but different: Exploring Plasmodium cell division during liver stage development
M Roques, A Bindschedler, R Beyeler… - PLoS …, 2023 - journals.plos.org
Plasmodium parasites have a complex life cycle alternating between a mosquito and a
vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium …
vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium …
[HTML][HTML] Systems biology of malaria explored with nonhuman primates
MR Galinski - Malaria journal, 2022 - Springer
Abstract “The Primate Malarias” book has been a uniquely important resource for multiple
generations of scientists, since its debut in 1971, and remains pertinent to the present day …
generations of scientists, since its debut in 1971, and remains pertinent to the present day …
[HTML][HTML] Plasmodium vivax latent liver infection is characterized by persistent hypnozoites, hypnozoite-derived schizonts, and time-dependent efficacy of primaquine
EL Flannery, N Kangwanrangsan, V Chuenchob… - … Therapy-Methods & …, 2022 - cell.com
Plasmodium vivax is a malaria-causing pathogen that establishes a dormant form in the liver
(the hypnozoite), which can activate weeks, months, or years after the primary infection to …
(the hypnozoite), which can activate weeks, months, or years after the primary infection to …
[HTML][HTML] Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets
AA Ruberto, SP Maher, A Vantaux… - Frontiers in Cellular …, 2022 - frontiersin.org
The resilience of Plasmodium vivax, the most widely-distributed malaria-causing parasite in
humans, is attributed to its ability to produce dormant liver forms known as hypnozoites …
humans, is attributed to its ability to produce dormant liver forms known as hypnozoites …
[HTML][HTML] A dual fluorescent Plasmodium cynomolgi reporter line reveals in vitro malaria hypnozoite reactivation
AM Voorberg-van Der Wel, AM Zeeman… - Communications …, 2020 - nature.com
Plasmodium vivax malaria is characterized by repeated episodes of blood stage infection
(relapses) resulting from activation of dormant stages in the liver, so-called hypnozoites …
(relapses) resulting from activation of dormant stages in the liver, so-called hypnozoites …
[HTML][HTML] Epigenetically regulated RNA-binding proteins signify malaria hypnozoite dormancy
CG Toenhake, A Voorberg-van der Wel, H Wu… - Cell Reports, 2023 - cell.com
Dormancy enables relapsing malaria parasites, such as Plasmodium vivax and cynomolgi,
to survive unfavorable conditions. It is enabled by hypnozoites, parasites remaining …
to survive unfavorable conditions. It is enabled by hypnozoites, parasites remaining …
[HTML][HTML] Plasmodium 6-Cysteine Proteins: Functional Diversity, Transmission-Blocking Antibodies and Structural Scaffolds
FMT Lyons, M Gabriela, WH Tham… - Frontiers in Cellular and …, 2022 - frontiersin.org
The 6-cysteine protein family is one of the most abundant surface antigens that are
expressed throughout the Plasmodium falciparum life cycle. Many members of the 6 …
expressed throughout the Plasmodium falciparum life cycle. Many members of the 6 …