The blood coagulation protein fibrinogen is deposited in the brain in a wide range of
neurological diseases and traumatic injuries with blood–brain barrier (BBB) disruption …

The contact activation system (CAS) and kallikrein/kinin system (KKS) are older recognized
biochemical pathways that include several proteins that skirt the fringes of the blood …

The amyloid-beta peptide (Aβ) is a driver of Alzheimer's disease (AD). Aβ monomers can
aggregate and form larger soluble (oligomers/protofibrils) and insoluble (fibrils) forms. There …

The contact system is a potent procoagulant and proinflammatory plasma protease cascade
that is initiated by binding (“contact”)-induced, auto-activation of factor XII zymogen. Formed …

Background: Cerebrovascular disease is a common comorbidity in patients with Alzheimer's
disease (AD). It is believed to contribute additively to the cognitive impairment and to lower …

Background In the past few decades, it has been demonstrated with animal models and
clinical studies that a chronic inflammatory process significantly contributes to Alzheimer's …

Inhibiting thrombosis without generating bleeding risks is a major challenge in medicine. A
promising solution may be the inhibition of coagulation factor XII (FXII), because its knock …

Hyperfibrinolysis is a systemic condition occurring in various clinical disorders such as
trauma, liver cirrhosis, and leukemia. Apart from increased bleeding tendency, the …

The societal burden of Alzheimer's disease (AD) is staggering, with current estimates
suggesting that 50 million people world-wide have AD. Identification of new therapeutic …

Contact activation is the surface-induced conversion of factor XII (FXII) zymogen to the
serine protease FXIIa. Blood-circulating FXII binds to negatively charged surfaces and this …