The chemical scaffold of theranostic radiopharmaceuticals: radionuclide, bifunctional chelator, and pharmacokinetics modifying linker

HA Holik, FM Ibrahim, AA Elaine, BD Putra, A Achmad… - Molecules, 2022 - mdpi.com
Therapeutic radiopharmaceuticals have been researched extensively in the last decade as
a result of the growing research interest in personalized medicine to improve diagnostic …

Theranostic advances in breast cancer in nuclear medicine

N Vahidfar, A Aghanejad, H Ahmadzadehfar… - International journal of …, 2021 - mdpi.com
The implication of 'theranostic'refers to targeting an identical receptor for diagnostic and
therapeutic purposes, by the same radioligand, simultaneously or separately. In regard to …

EANM position paper on the role of radiobiology in nuclear medicine

A Aerts, U Eberlein, S Holm, R Hustinx… - European journal of …, 2021 - Springer
With an increasing variety of radiopharmaceuticals for diagnostic or therapeutic nuclear
medicine as valuable diagnostic or treatment option, radiobiology plays an important role in …

Potential for production of medical radionuclides with on-line isotope separation at the ISAC facility at TRIUMF and particular discussion of the examples of 165Er and …

DE Fiaccabrino, P Kunz, V Radchenko - Nuclear Medicine and Biology, 2021 - Elsevier
Production of medical radionuclides with ISOL facilities is a unique production method that
may provide access to preclinical quantities of some rare and potent radionuclides for …

A review on tumor control probability (TCP) and preclinical dosimetry in targeted radionuclide therapy (TRT)

K Spoormans, M Crabbé, L Struelens… - Pharmaceutics, 2022 - mdpi.com
Targeted radionuclide therapy (TRT) uses radiopharmaceuticals to specifically irradiate
tumor cells while sparing healthy tissue. Response to this treatment highly depends on the …

The role of theragnostics in breast cancer: A systematic review of the last 12 years

M Balma, V Liberini, A Buschiazzo… - Current medical …, 2023 - ingentaconnect.com
Background: Breast cancer is the most common malignancy in women, with high morbidity
and mortality. Molecular alterations in breast cancer involve the expression or upregulation …

Gallium: New developments and applications in radiopharmaceutics

PJ Blower, R Cusnir, A Darwesh, NJ Long… - Advances in Inorganic …, 2021 - Elsevier
The chemistry of gallium has played a key role in nuclear medicine for half a century. Its
applications have centered around two principal radionuclides, gallium-67 and gallium-68 …

[HTML][HTML] Targeted Auger electron-emitter therapy: Radiochemical approaches for thallium-201 radiopharmaceuticals

A Rigby, JE Blower, PJ Blower, SYA Terry… - Nuclear medicine and …, 2021 - Elsevier
Introduction Thallium-201 is a radionuclide that has previously been used clinically for
myocardial perfusion scintigraphy. Although in this role it has now been largely replaced by …

Non-invasive radionuclide imaging of trace metal trafficking in health and disease:“PET metallomics”

G Firth, JE Blower, JJ Bartnicka, A Mishra… - RSC Chemical …, 2022 - pubs.rsc.org
Several specific metallic elements must be present in the human body to maintain health
and function. Maintaining the correct quantity (from trace to bulk) and location at the cell and …

In Vivo Trafficking of the Anticancer Drug Tris (8-Quinolinolato) Gallium (III)(KP46) by Gallium-68/67 PET/SPECT Imaging

AMF Darwesh, C Imberti, JJ Bartnicka, F Al-Salemee… - Molecules, 2023 - mdpi.com
KP46 (tris (hydroxyquinolinato) gallium (III)) is an experimental, orally administered
anticancer drug. Its absorption, delivery to tumours, and mode of action are poorly …