Although the mysteries of its history and origin remain unsolved, worldwide cultivation and
high‐demand production for citrus fruit (genus Citrus in family Rutaceae) make it stand high …

Background It has been reported that neural tube defects (NTD) can be prevented with
periconceptional folic acid supplementation. The effects of different doses, forms and …

Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of this
review paper is to show the characteristics of common and severe neural-tube defects …

Objectives: To assess the methodological quality of intention to treat analysis as reported in
randomised controlled trials in four large medical journals. Design: Survey of all reports of …

The present Consultation is part of a long series of expert consultations, which have as a
primary objective to review the state of knowledge on the role of various nutrients in the …

Each year spina bifida and anencephaly, the two most common forms of neural-tube defects,
occur in 1 in 1000 pregnancies in the United States1 and an estimated 300,000 or more …

With 4 mg folic acid daily, it may take 20 weeks to reach red-blood-cell folate levels between
1050 and 1340 nmol/L, optimal for reduction of the neural tube defect risk. Therefore, folic …

Folate functions in multiple coenzyme forms in acceptance, redox processing and transfer of
one-carbon units, including nucleotides and certain amino acids. Folate-requiring metabolic …

ContextDaily consumption of 400 µg of folic acid before conception and during early
pregnancy dramatically reduces the occurrence of neural tube defects (NTDs). Before food …

Pregnancy is a time of tremendous growth and physiological changes for mother and her
developing fetus with lifelong implications for the child. The concert of actions that must …