DNA replication in eukaryotic cells initiates from large numbers of sites called replication
origins. Initiation of replication from these origins must be tightly controlled to ensure the …

▪ Abstract The maintenance of the eukaryotic genome requires precisely coordinated
replication of the entire genome each time a cell divides. To achieve this coordination …

The origin recognition complex (ORC) is essential for initiation of eukaryotic chromosome
replication as it loads the replicative helicase—the minichromosome maintenance (MCM) …

The recognition of distinctly modified histones by specialized 'effector'proteins constitutes a
key mechanism for transducing molecular events at chromatin to biological outcomes …

Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …

▪ Abstract Genomes are organized into active regions known as euchromatin and inactive
regions known as heterochromatin, or silenced chromatin. This review describes …

▪ Abstract The MCM proteins are essential replication initiation factors originally identified as
proteins required for minichromosome maintenance in Saccharomyces cerevisiae. The best …

Heterochromatin, defined by histone H3 lysine 9 methylation (H3K9me), spreads across
large domains and can be epigenetically inherited in a self-propagating manner …

Protein localization data are a valuable information resource helpful in elucidating
eukaryotic protein function. Here, we report the first proteome-scale analysis of protein …

We have sequenced and annotated the genome of the filamentous ascomycete Ashbya
gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the …