Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …

Oxidative stress is generally considered as the consequence of an imbalance between pro-
and antioxidants species, which often results into indiscriminate and global damage at the …

Although there are seven mammalian sirtuins (SIRT1-7), little is known about their
expression in the aging brain. To characterize the change (s) in mRNA and protein …

Background Selenium and coenzyme Q10 are both necessary for optimal cell function in the
body. The intake of selenium is low in Europe, and the endogenous production of coenzyme …

Objective Oxidative stress (OS) has been previously linked to the aging process, as have
some diseases and geriatric syndromes as frailty and sarcopenia. The aim of the present …

The world's population over 60 years is growing rapidly, reaching 22% of the global
population in the next decades. Despite the increase in global longevity, individual …

Sirtuins are NAD+-dependent enzymes that regulate a large number of cellular pathways
and are related to aging and age-associated diseases. In recent years, the role of sirtuins in …

Background Selenium and coenzyme Q10 are important antioxidants in the body. As the
intake of selenium is low in Europe, and the endogenous production of coenzyme Q10 …

FOXO3 is consistently annotated as a human longevity gene. However, functional variants
and underlying mechanisms for the association remain unknown. Here, we perform …

Reactive oxygen species (ROS) are molecules involved in signal transduction pathways
with both beneficial and detrimental effects on human cells. ROS are generated by many …