The effect of dexmedetomidine on delirium and agitation in patients in intensive care: systematic review and meta‐analysis with trial sequential analysis

KT Ng, CJ Shubash, JS Chong - Anaesthesia, 2019 - Wiley Online Library
Delirium is common in intensive care patients. Dexmedetomidine is increasingly used for
sedation in this setting, but its effect on delirium remains unclear. The primary aim of this …

Dexmedetomidine for reduction of atrial fibrillation and delirium after cardiac surgery (DECADE): a randomised placebo-controlled trial

A Turan, A Duncan, S Leung, N Karimi, J Fang, G Mao… - The Lancet, 2020 - thelancet.com
Background Atrial fibrillation and delirium are common consequences of cardiac surgery.
Dexmedetomidine has unique properties as sedative agent and might reduce the risk of …

Recent advances in the clinical value and potential of dexmedetomidine

X Liu, Y Li, L Kang, Q Wang - Journal of Inflammation Research, 2021 - Taylor & Francis
Dexmedetomidine, a highly selective α2-adrenoceptor agonist, has sedative, anxiolytic,
analgesic, sympatholytic, and opioid-sparing properties and induces a unique sedative …

Effect of dexmedetomidine on hemodynamic responses to tracheal intubation: A meta-analysis with meta-regression and trial sequential analysis.

A De Cassai, A Boscolo, F Geraldini… - Journal of clinical …, 2021 - Elsevier
Study objective An uncontrolled adrenergic response during tracheal intubation may lead to
life-threatening complications. Dexmedetomidine binds to α2-receptors and may attenuate …

The state-of-the-art pharmacotherapeutic options for the treatment of chronic non-cancer pain

RS D'Souza, B Langford, RE Wilson… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Pharmacotherapeutic options continue to expand for the treatment of chronic
non-cancer pain. There has been an increasing emphasis on multimodal analgesia. This …

Review of nonopioid multimodal analgesia for surgical and trauma patients

S George, M Johns - American Journal of Health-System …, 2020 - academic.oup.com
Purpose Pain is a frequent finding in surgical and trauma patients, and effective pain control
remains a common challenge in the hospital setting. Opioids have traditionally been the …

Effect of dexmedetomidine on postoperative nausea and vomiting in patients under general anaesthesia: an updated meta-analysis of randomised controlled trials

W Zhao, J Li, N Wang, Z Wang, M Zhang, H Zhang… - BMJ open, 2023 - bmjopen.bmj.com
Objectives To explore the effect of dexmedetomidine (DEX) on postoperative nausea and
vomiting (PONV) in adult patients after general anaesthesia. Design Systematic review and …

The effect of low-dose dexmedetomidine on pain and inflammation in patients undergoing laparoscopic hysterectomy

J Lee, HW Hwang, JY Jeong, YM Kim, C Park… - Journal of Clinical …, 2022 - mdpi.com
Dexmedetomidine has sedative, sympatholytic, analgesic, and anti-inflammatory effects. We
investigated the effects of intraoperative dexmedetomidine infusion without a loading dose …

Multimodal analgesia for accelerated rehabilitation after total knee arthroplasty: a randomized, double-blind, controlled trial on the effect of the co-application of local …

C Gao, T Huang, K Wu, W Zhang, S Wang, X Chai… - Brain Sciences, 2022 - mdpi.com
Background: Multimodal postoperative pain regimens are widely used following total knee
arthroplasty (TKA). However, there are few studies on the rehabilitation of the co-application …

Effect of dexmedetomidine on nociception level index-guided remifentanil antinociception: a randomised controlled trial

S Coeckelenbergh, S Doria, D Patricio… - European Journal of …, 2021 - journals.lww.com
BACKGROUND The effect of dexmedetomidine on Nociception Level Index-guided
(Medasense, Israel) antinociception to reduce intra-operative opioid requirements has not …