During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

The mitogen-activated protein kinases (MAPK) pathway, often known as the RAS-RAF-MEK-
ERK signal cascade, functions to transmit upstream signals to its downstream effectors to …

Cytokine storm is suggested as one of the major pathological characteristics of SARS-CoV-2
infection, although the mechanism for initiation of a hyper-inflammatory response, and multi …

Mounting evidence indicates that inflammatory cytokines contribute to the development of
depression in both medically ill and medically healthy individuals. Cytokines are important …

The potential contribution of chronic inflammation to the development of neuropsychiatric
disorders such as major depression has received increasing attention. Elevated biomarkers …

The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to
interpret a wide range of external signals and respond appropriately by generating a …

P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory
diseases. Alzheimer's disease (AD) is characterized by the presence of amyloid plaques …

The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential.
Consequently, the search for new pyrazole-based compounds is of great interest to the …

Mitogen-activated protein kinases (MAPKs) mediate a wide variety of cellular behaviors in
response to extracellular stimuli. One of the main subgroups, the p38 MAP kinases, has …