Paracetamol: a review of guideline recommendations

U Freo, C Ruocco, A Valerio, I Scagnol… - Journal of clinical …, 2021 - mdpi.com
Musculoskeletal pain conditions are age-related, leading contributors to chronic pain and
pain-related disability, which are expected to rise with the rapid global population aging …

Caring for patients with pain during the COVID‐19 pandemic: consensus recommendations from an international expert panel

H Shanthanna, NH Strand, DA Provenzano… - …, 2020 - Wiley Online Library
Chronic pain causes significant suffering, limitation of daily activities and reduced quality of
life. Infection from COVID‐19 is responsible for an ongoing pandemic that causes severe …

The link between depression and chronic pain: neural mechanisms in the brain

J Sheng, S Liu, Y Wang, R Cui, X Zhang - Neural plasticity, 2017 - Wiley Online Library
Chronic pain, as a stress state, is one of the critical factors for determining depression, and
their coexistence tends to further aggravate the severity of both disorders. Unfortunately …

Opioid abuse in chronic pain—misconceptions and mitigation strategies

ND Volkow, AT McLellan - New England Journal of Medicine, 2016 - Mass Medical Soc
Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Regulation of µ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance

JT Williams, SL Ingram, G Henderson, C Chavkin… - Pharmacological …, 2013 - Elsevier
Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective
drugs known for acute relief of severe pain. A major problem in treating painful conditions is …

Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study

A Capano, R Weaver, E Burkman - Postgraduate medicine, 2020 - Taylor & Francis
Context: Chronic pain is highly prevalent in most of the industrialized nations around the
world. Despite the documented adverse effects, opioids are widely used for pain …

The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies

Y Han, W Yan, Y Zheng, MZ Khan, K Yuan… - Translational psychiatry, 2019 - nature.com
Fentanyl is a powerful opioid anesthetic and analgesic, the use of which has caused an
increasing public health threat in the United States and elsewhere. Fentanyl was initially …

Pain management during the COVID-19 pandemic

SN El-Tallawy, R Nalamasu, JV Pergolizzi, C Gharibo - Pain and Therapy, 2020 - Springer
Chronic pain management during the coronavirus disease 2019 (COVID-19) pandemic is a
challenging process, especially with growing evidence that COVID-19 infection is …

The burden of chronic low back pain: clinical comorbidities, treatment patterns, and health care costs in usual care settings

M Gore, A Sadosky, BR Stacey, KS Tai, D Leslie - Spine, 2012 - journals.lww.com
Study Design. Retrospective analysis of an insurance claims database. Objective. To
examine the comorbidities, treatment patterns, health care resource utilization, and direct …

Management of persistent pain in the older patient: a clinical review

UE Makris, RC Abrams, B Gurland, MC Reid - Jama, 2014 - jamanetwork.com
Importance Persistent pain is highly prevalent, costly, and frequently disabling in later life.
Objective To describe barriers to the management of persistent pain among older adults …