Molecular mechanisms of drug resistance
DB Longley, PG Johnston - The Journal of Pathology: A Journal …, 2005 - Wiley Online Library
Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …
Apoptosis and cancer: the genesis of a research field
TG Cotter - Nature Reviews Cancer, 2009 - nature.com
In multicellular organisms, the total number of cells is a balance between the cell-generating
effects of mitosis and cell death that is induced through apoptosis. A disruption of this …
effects of mitosis and cell death that is induced through apoptosis. A disruption of this …
Death receptors in chemotherapy and cancer
KM Debatin, PH Krammer - Oncogene, 2004 - nature.com
Apoptosis, the cell's intrinsic death program, is a key regulator of tissue homeostasis. An
imbalance between cell death and proliferation may result in tumor formation. Also, killing of …
imbalance between cell death and proliferation may result in tumor formation. Also, killing of …
Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer
GM Callagy, MJ Webber, PDP Pharoah, C Caldas - BMC cancer, 2008 - Springer
Background A number of protein markers have been investigated as prognostic adjuncts in
breast cancer but their translation into clinical practice has been impeded by a lack of …
breast cancer but their translation into clinical practice has been impeded by a lack of …
Evaluation of apoptosis-associated protein (Bcl-2, Bax, cleaved caspase-3 and p53) expression in canine mammary tumors: An immunohistochemical and prognostic …
I Dolka, M Król, R Sapierzyński - Research in veterinary science, 2016 - Elsevier
Apoptosis is an important process involved in pathogenesis and progression of neoplasia.
However, it has been not so far extensively investigated in canine mammary tumors (CMTs) …
However, it has been not so far extensively investigated in canine mammary tumors (CMTs) …
[PDF][PDF] Chemoresistance in solid tumours
TR Wilson, DB Longley, PG Johnston - Annals of Oncology, 2006 - academia.edu
Drug resistance is a major factor that limits the effectiveness of chemotherapy. Tumours can
be intrinsically resistant prior to chemotherapy, or resistance may be acquired during …
be intrinsically resistant prior to chemotherapy, or resistance may be acquired during …
Gene expression profiling in biopsied tumor tissues
JB Baker, MT Cronin, MC Kiefer, S Shak… - US Patent …, 2006 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
28045456&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
28045456&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Apoptosis genes and resistance to cancer therapy: what does the experimental and clinical data tell us?
The dominant paradigm in cancer treatment is that cancer cells die from the common
pathway of apoptosis subsequent to DNA damage by anticancer agents and that cells …
pathway of apoptosis subsequent to DNA damage by anticancer agents and that cells …
SCARA5 plays a critical role in the progression and metastasis of breast cancer by inactivating the ERK1/2, STAT3, and AKT signaling pathways
K You, F Su, L Liu, X Lv, J Zhang, Y Zhang… - Molecular and Cellular …, 2017 - Springer
Scavenger receptor class A member 5 (SCARA5) is a candidate anti-oncogene in several
malignancies. However, whether SCARA5 is a suppressor gene in breast cancer and its role …
malignancies. However, whether SCARA5 is a suppressor gene in breast cancer and its role …
Changes in tumour biological markers during primary systemic chemotherapy (PST)
H Neubauer, C Gall, U Vogel, R Hornung… - Anticancer …, 2008 - ar.iiarjournals.org
Background: The influence of primary systemic therapy (PST) on the expression of relevant
therapeutic markers is still under investigation. Patients and Methods: Corresponding …
therapeutic markers is still under investigation. Patients and Methods: Corresponding …