Molecular mechanisms of drug resistance

DB Longley, PG Johnston - The Journal of Pathology: A Journal …, 2005 - Wiley Online Library
Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …

Apoptosis and cancer: the genesis of a research field

TG Cotter - Nature Reviews Cancer, 2009 - nature.com
In multicellular organisms, the total number of cells is a balance between the cell-generating
effects of mitosis and cell death that is induced through apoptosis. A disruption of this …

Death receptors in chemotherapy and cancer

KM Debatin, PH Krammer - Oncogene, 2004 - nature.com
Apoptosis, the cell's intrinsic death program, is a key regulator of tissue homeostasis. An
imbalance between cell death and proliferation may result in tumor formation. Also, killing of …

Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer

GM Callagy, MJ Webber, PDP Pharoah, C Caldas - BMC cancer, 2008 - Springer
Background A number of protein markers have been investigated as prognostic adjuncts in
breast cancer but their translation into clinical practice has been impeded by a lack of …

Evaluation of apoptosis-associated protein (Bcl-2, Bax, cleaved caspase-3 and p53) expression in canine mammary tumors: An immunohistochemical and prognostic …

I Dolka, M Król, R Sapierzyński - Research in veterinary science, 2016 - Elsevier
Apoptosis is an important process involved in pathogenesis and progression of neoplasia.
However, it has been not so far extensively investigated in canine mammary tumors (CMTs) …

[PDF][PDF] Chemoresistance in solid tumours

TR Wilson, DB Longley, PG Johnston - Annals of Oncology, 2006 - academia.edu
Drug resistance is a major factor that limits the effectiveness of chemotherapy. Tumours can
be intrinsically resistant prior to chemotherapy, or resistance may be acquired during …

Gene expression profiling in biopsied tumor tissues

JB Baker, MT Cronin, MC Kiefer, S Shak… - US Patent …, 2006 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
28045456&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Apoptosis genes and resistance to cancer therapy: what does the experimental and clinical data tell us?

JM Brown, G Wilson - Cancer Biology & Therapy, 2003 - Taylor & Francis
The dominant paradigm in cancer treatment is that cancer cells die from the common
pathway of apoptosis subsequent to DNA damage by anticancer agents and that cells …

SCARA5 plays a critical role in the progression and metastasis of breast cancer by inactivating the ERK1/2, STAT3, and AKT signaling pathways

K You, F Su, L Liu, X Lv, J Zhang, Y Zhang… - Molecular and Cellular …, 2017 - Springer
Scavenger receptor class A member 5 (SCARA5) is a candidate anti-oncogene in several
malignancies. However, whether SCARA5 is a suppressor gene in breast cancer and its role …

Changes in tumour biological markers during primary systemic chemotherapy (PST)

H Neubauer, C Gall, U Vogel, R Hornung… - Anticancer …, 2008 - ar.iiarjournals.org
Background: The influence of primary systemic therapy (PST) on the expression of relevant
therapeutic markers is still under investigation. Patients and Methods: Corresponding …