Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Elevation of cytosolic Ca2+ levels through the activation of store-operated Ca2+ release-
activated Ca2+ (CRAC) channels is involved in mediating a disparate array of cellular …

Microglia respond to CNS injuries and diseases with complex reactions, often called
“activation.” A pro-inflammatory phenotype (also called classical or M1 activation) lies at one …

Store-operated calcium (Ca 2+) entry (SOCE) mediated by STIM/Orai proteins is a
ubiquitous pathway that controls many important cell functions including proliferation and …

Neuroinflammation and associated neuronal dysfunction mediated by activated microglia
play an important role in the pathogenesis of Alzheimer disease (AD). Microglia are …

Abstract Store-operated Ca 2+ entry (SOCE) is an important Ca 2+ influx pathway in many
non-excitable and some excitable cells. It is regulated by the filling state of intracellular Ca …

Microglial cells derive from fetal macrophages which immigrate into and disseminate
throughout the central nervous system (CNS) in early embryogenesis. After settling in the …

Alzheimer's disease (AD) begins with a decline in cognition followed by neuronal cell death
and dementia. These changes have been linked to a deregulation of Ca2+ signalling …

Accumulating evidence suggests that neuroimmune interactions contribute to pathological
pain. Transient receptor potential melastatin 2 (TRPM2) is a nonselective Ca2+-permeable …

Plasma-membrane-localized Orai1 ion channel subunits interacting with ER-localized
STIM1 molecules comprise the major subunit composition responsible for calcium release …