ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

Autophagy is a highly conserved catabolic process cells use to maintain their homeostasis
by degrading misfolded, damaged and excessive proteins, nonfunctional organelles, foreign …

Autophagosomes are unique organelles that form de novo as double-membrane vesicles
engulfing cytosolic material for destruction. Their biogenesis involves membrane …

LC3-associated endocytosis (LANDO) is a noncanonical function of the autophagy
machinery, in which LC3 (microtubule-associated protein light chain) is conjugated to rab5 …

Clathrin-mediated endocytosis is initiated by a network of weakly interacting proteins
through a poorly understood mechanism. Ede1, the yeast homolog of mammalian Eps15, is …

Macroautophagy/autophagy is an intracellular degradation process central to cellular
homeostasis and defense against pathogens in eukaryotic cells. Regulation of autophagy …

Traditionally, structural biologists approach the complexity of cellular proteomes in a
reductionist manner. Proteomes are fractionated, their molecular components purified and …

Protein recruitment to DNA break sites is an integral part of the DNA damage response
(DDR). Elucidation of the hierarchy and temporal order with which DNA damage sensors as …

In the past almost 15 years, we witnessed the birth of a new scientific field focused on the
existence, formation, biological functions, and disease associations of membraneless …

Aggregation of proteins containing expanded polyglutamine (polyQ) repeats is the
cytopathologic hallmark of a group of dominantly inherited neurodegenerative diseases …