Antiplatelet medications comprise the cornerstone of treatment for diseases that involve
arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral …

The platelet C-type lectin-like receptor CLEC-2 drives inflammation-driven venous
thrombosis in mouse models of thrombo-inflammatory disease with a minimal effect on …

摘要21 世纪初诞生的超分辨光学成像技术凭借纳米级空间分辨率, 低损制样等优点,
迅速发展成为生命科学研究中不可或缺的技术手段. 其中单分子定位超分辨成像(SMLM) …

Alternate splicing is among the regulatory mechanisms imparting functional diversity in
proteins. Studying protein isoforms generated through alternative splicing is therefore critical …

Platelets are blood cells responsible for vascular integrity preservation. The activation of
platelet receptor C-type lectin-like receptor II-type (CLEC-2) could partially mediate the latter …

CLEC-2 is a target for a new class of antiplatelet agent. Clustering of CLEC-2 leads to
phosphorylation of a cytosolic YxxL and binding of the tandem SH2 domains in Syk …

Charge interactions play a critical role in the activation of the innate immune system by
damage-and pathogen-associated molecular pattern receptors. The ability of these …

Key Points Human, canine, ovine, and porcine platelets exhibit disparate biophysical
signatures, whereas human and murine platelets are similar. Multiple biophysical …

Beyond the role of mitochondria in apoptosis initiation/execution, some mitochondrial
adaptations support the metastasis and chemoresistance of cancer cells. This highlights …

Conclusions Some of the platelet responses are critical for platelet plug formation (integrins,
dense granules, thromboxane A2), while others are involved in blood coagulation …