Cancer is one of the leading health hazards and the prominent cause of death in the world.
A number of anticancer agents are currently in clinical practice and used for treatment of …

Dihydropyrimidinones are heterocycles with a pyrimidine moiety in the ring nucleus, which,
in recent decades, have aroused interest in medicinal chemistry due to alleged versatile …

Abstract The 1, 3, 4‐oxadiazole nucleus is a biologically imperative scaffold possesses
numerous biological activities. The broad and potent activity of 1, 3, 4‐oxadiazole and their …

The synthesis and differential antiproliferative activity of monastrol (1a), oxo-monastrol (1b)
and eight oxygenated derivatives 3a, b–6a, b on seven human cancer cell lines are …

Kinesin spindle protein (KSP), a member of the kinesin superfamily of microtubule-based
motors, plays a critical role in mitosis as it mediates centrosome separation and bipolar …

Abstract Gain of chromosome 1q31–1q32 is seen in> 50% of retinoblastoma and is common
in other tumors. To define the minimal 1q region of gain, we determined genomic copy …

Several kinesin-5 motors (kinesin-5s) exhibit bidirectional motility. The mechanism of such
motility remains unknown. Bidirectional kinesin-5s share a long N-terminal nonmotor …

Development of new, targeted antibreast cancer drug which can treat both the hormone
receptor (positive and negative) breast cancers is a very challenging task. The concept of …

A series of dihydropyrimidine (DHPM) derivatives bearing 1, 3, 4-oxadiazole moiety was
designed and synthesized as monastrol analogues. The new compounds were screened for …

Gain of chromosome 1q is a hallmark of breast cancer, and likely reflects oncogene
amplification. We previously identified mitotic kinesin KIF14 (kinesin family member 14) as …