[HTML][HTML] The TNBS-induced colitis animal model: An overview

E Antoniou, GA Margonis, A Angelou, A Pikouli… - Annals of medicine and …, 2016 - Elsevier
Background Despite recent advances the pathogenesis of Crohn's disease remains
incompletely understood. A variety of animal models have been utilized in an effort to …

Biased signaling of protease-activated receptors

P Zhao, M Metcalf, NW Bunnett - Frontiers in endocrinology, 2014 - frontiersin.org
In addition to their role in protein degradation and digestion, proteases can also function as
hormone-like signaling molecules that regulate vital patho-physiological processes …

Targeting proteinase-activated receptors: therapeutic potential and challenges

R Ramachandran, F Noorbakhsh, K DeFea… - Nature reviews Drug …, 2012 - nature.com
Abstract Proteinase-activated receptors (PARs), a family of four seven-transmembrane G
protein-coupled receptors, act as targets for signalling by various proteolytic enzymes. PARs …

Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia

QT Le, JJ Lyons, AN Naranjo, A Olivera… - Journal of Experimental …, 2019 - rupress.org
Both α-tryptase and β-tryptase are preferentially expressed by human mast cells, but the
purpose of α-tryptase is enigmatic, because its tetramers lack protease activity, whereas β …

Molecular mechanisms regulating proteinase‐activated receptors (PARs)

A Chandrabalan, R Ramachandran - The FEBS Journal, 2021 - Wiley Online Library
Proteinase‐activated receptors (PARs) are a four‐member family of G protein‐coupled
receptors defined by their irreversible proteolytic mechanism of activation. PARs have …

Proteinase-activated receptors (PARs)–focus on receptor-receptor-interactions and their physiological and pathophysiological impact

F Gieseler, H Ungefroren, U Settmacher… - Cell Communication and …, 2013 - Springer
Proteinase-activated receptors (PARs) are a subfamily of G protein-coupled receptors
(GPCRs) with four members, PAR 1, PAR 2, PAR 3 and PAR 4, playing critical functions in …

Biased signalling and proteinase‐activated receptors (PAR s): targeting inflammatory disease

MD Hollenberg, K Mihara, D Polley… - British journal of …, 2014 - Wiley Online Library
Although it has been known since the 1960s that trypsin and chymotrypsin can mimic
hormone action in tissues, it took until the 1990s to discover that serine proteinases can …

Protease-activated receptor-2 regulates neuro-epidermal communication in atopic dermatitis

T Buhl, A Ikoma, C Kempkes, F Cevikbas… - Frontiers in …, 2020 - frontiersin.org
Background: Activation of protease-activated receptor-2 (PAR2) has been implicated in
inflammation, pruritus, and skin barrier regulation, all characteristics of atopic dermatitis …

Diet‐induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

J Lim, A Iyer, L Liu, JY Suen, RJ Lohman… - The FASEB …, 2013 - Wiley Online Library
Excessive uptake of fatty acids and glucose by adipose tissue triggers adipocyte dysfunction
and infiltration of immune cells. Altered metabolic homeostasis in adipose tissue promotes …

An antagonist of human protease activated receptor‐2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen‐induced arthritis in …

RJ Lohman, AJ Cotterell, GD Barry, L Liu… - The FASEB …, 2012 - Wiley Online Library
Multiple serine proteases exert proinflammatory actions by signaling through protease‐
activated receptor‐2 (PAR2) on the cell surface. Although inhibitors of individual proteases …