[HTML][HTML] Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
H Zhao, T Ming, S Tang, S Ren, H Yang, M Liu, Q Tao… - Molecular cancer, 2022 - Springer
Abstract Background The Wnt signaling pathway is a complex network of protein interactions
that functions most commonly in embryonic development and cancer, but is also involved in …
that functions most commonly in embryonic development and cancer, but is also involved in …
[HTML][HTML] Selective autophagy of intracellular organelles: recent research advances
Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …
that degrades over-abundant or damaged organelles, large protein aggregates and …
[HTML][HTML] LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619 …
C Zhou, C Yi, Y Yi, W Qin, Y Yan, X Dong, X Zhang… - Molecular cancer, 2020 - Springer
Background Pancreatic cancer is one of the most lethal malignancies and has an extremely
poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major …
poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major …
[HTML][HTML] A diversity of selective autophagy receptors determines the specificity of the autophagy pathway
The clearance of surplus, broken, or dangerous components is key for maintaining cellular
homeostasis. The failure to remove protein aggregates, damaged organelles, or intracellular …
homeostasis. The failure to remove protein aggregates, damaged organelles, or intracellular …
[HTML][HTML] The regulation of β-catenin activity and function in cancer: therapeutic opportunities
S Shang, F Hua, ZW Hu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Wnt/β-catenin signaling is an evolutionarily conserved and versatile pathway that is known
to be involved in embryonic development, tissue homeostasis and a wide variety of human …
to be involved in embryonic development, tissue homeostasis and a wide variety of human …
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases
Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
STING directly activates autophagy to tune the innate immune response
STING (stimulator of interferon genes) is a central molecule that binds to cyclic dinucleotides
produced by the cyclic GMP-AMP synthase (cGAS) to activate innate immunity against …
produced by the cyclic GMP-AMP synthase (cGAS) to activate innate immunity against …
[HTML][HTML] Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy
HT Chen, H Liu, MJ Mao, Y Tan, XQ Mo, XJ Meng… - Molecular cancer, 2019 - Springer
Autophagy is a highly conserved catabolic process that mediates degradation of pernicious
or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and …
or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and …
[HTML][HTML] Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling
Cellular homeostasis and adaptation to various environmental conditions are importantly
regulated by the sophisticated mechanism of autophagy and its crosstalk with Wnt signaling …
regulated by the sophisticated mechanism of autophagy and its crosstalk with Wnt signaling …
[HTML][HTML] Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy
Selective autophagy ensures recognition and removal of various cytosolic cargos. Hence,
aggregated proteins, damaged organelles, or pathogens are enclosed into the double …
aggregated proteins, damaged organelles, or pathogens are enclosed into the double …