Meta-analyses of genome-wide association studies (meta-GWASs) and candidate gene
studies have identified genetic variants associated with cardiovascular diseases, metabolic …

Dysfunction of the serotonin 1A receptor (5-HT1A) may play a role in the genesis of major
depressive disorder (MDD). Here we review the pharmacological, post-mortem, positron …

Abstract Rationale Serotonin (5-HT) neurotransmission is intimately linked to anxiety and
depression and a diverse body of evidence supports the involvement of the main inhibitory …

This systematic review summarizes pharmacogenetic studies on antidepressant response
and side effects. Out of the 17 genes we reviewed, 8 genes were entered into the meta …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Nowadays depression is considered as a systemic illness with different biological
mechanisms involved in its etiology, including inflammatory response, hypothalamic …

Major depressive disorder (MDD) is a common and highly heterogeneous psychiatric
disorder encompassing a spectrum of symptoms involving deficits to a range of cognitive …

A number of candidate gene studies focused on major depression (MD) and antidepressant
(AD) efficacy have been carried out, but results mainly remain inconclusive. We performed a …

Personalized medicine—the adaptation of therapies based on an individual's genetic and
molecular profile—is one of the most promising aspects of modern medicine. The …

The serotonin-1A (5-HT1A) receptor serves as a hub to regulate the activity and actions of
the serotonin system, and is expressed both as a presynaptic autoreceptor on raphe …