Abstract tRNAs are key adaptor molecules that decipher the genetic code during translation
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …

RNA modifications have been historically considered as fine-tuning chemo-structural
features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has …

Summary tRNA is the most extensively modified RNA in cells. On average, a bacterial tRNA
contains 8 modifications per molecule and a eukaryotic tRNA contains 13 modifications per …

Post-transcriptional modification of RNA is an important determinant of RNA quality control,
translational efficiency, RNA-protein interactions and stress response. This is illustrated by …

Transfer RNA (tRNA) have been harbingers of many paradigms in RNA biology. They are
among the first recognized noncoding RNA (ncRNA) playing fundamental roles in RNA …

Eukaryotic transfer RNAs contain on average 14 modifications. Investigations of their
biological functions require the determination of the modification sites and the dynamic …

Transfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic
information organized in mRNA codons, translating them into the code of 20 amino acids. To …

To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic
pathways of the majority of tRNA modifications include a methylation step (s). Recent studies …

Transfer RNA (tRNA) modifications enhance the efficiency, specificity and fidelity of
translation in all organisms. The anticodon modification mcm5s2U34 is required for normal …

The regulation of gene expression in response to stress is an essential cellular protection
mechanism. Recent advances in tRNA modification analysis and genome-based codon bias …