BACKGROUND The discovery of kisspeptin as key central regulator of GnRH secretion has
led to a new level of understanding of the neuroendocrine regulation of human reproduction …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …

Gonadotropin-releasing hormone (GnRH) is the central regulator of gonadotropins, which
stimulate gonadal function. Hypothalamic neurons that produce kisspeptin and neurokinin B …

Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

Reproduction is required for the survival of all mammalian species, and thousands of
essential'sex'genes are conserved through evolution. Basic research helps to define these …

Mammalian reproductive function depends upon a neuroendocrine circuit that evokes the
pulsatile release of gonadotropin hormones (luteinizing hormone and follicle-stimulating …

The G protein-coupled receptor Gpr54 and its ligand metastin (derived from the Kiss1 gene
product kisspeptin) are key gatekeepers of sexual maturation. Gpr54 knockout mice …

Kisspeptin and its receptor GPR54 have recently been identified as key signaling partners in
the neural control of fertility in animal models and humans. The gonadotropin-releasing …

Puberty onset is initiated by activation of neurons that secrete gonadotropin-releasing
hormone (GnRH). The timing and progression of puberty may depend upon temporal …