The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

Y Han, J Yang, J Fang, Y Zhou, E Candi… - … and Targeted Therapy, 2022 - nature.com
Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …

A guide to assessing cellular senescence in vitro and in vivo

E González‐Gualda, AG Baker, L Fruk… - The FEBS …, 2021 - Wiley Online Library
Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …

[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy

M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

NC Noronha, A Mizukami, C Caliári-Oliveira… - Stem cell research & …, 2019 - Springer
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …

Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application

H Caplan, SD Olson, A Kumar, M George… - Frontiers in …, 2019 - frontiersin.org
For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …

Flow cytometry: principles, applications and recent advances

SM Manohar, P Shah, A Nair - Bioanalysis, 2021 - Taylor & Francis
Flow cytometry (FCM) is a sophisticated technique that works on the principle of light
scattering and fluorescence emission by the specific fluorescent probe-labeled cells as they …

Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO to promote immune privilege in the tumour microenvironment

C Zhou, Y Zhang, R Yan, L Huang, AL Mellor… - Cell Death & …, 2021 - nature.com
Clinical response to immunotherapy is closely associated with the immunosuppressive
tumour microenvironment (TME), and influenced by the dynamic interaction between tumour …

Human macrophage migration inhibitory factor potentiates mesenchymal stromal cell efficacy in a clinically relevant model of allergic asthma

IJ Hawthorne, H Dunbar, C Tunstead, T Schorpp… - Molecular Therapy, 2023 - cell.com
Current asthma therapies focus on reducing symptoms but fail to restore existing structural
damage. Mesenchymal stromal cell (MSC) administration can ameliorate airway …

Mesenchymal stromal cell therapeutic potency is dependent upon viability, route of delivery, and immune match

J Giri, J Galipeau - Blood advances, 2020 - ashpublications.org
Culture-adapted bone marrow mesenchymal stromal cells (MSCs) deploy paracrine anti-
inflammatory and tissue regenerative functionalities that can be harnessed as a living cell …

The influence of hypoxia and IFN-γ on the proteome and metabolome of therapeutic mesenchymal stem cells

HM Wobma, MA Tamargo, S Goeta, LM Brown… - Biomaterials, 2018 - Elsevier
Over the past 15 years, mesenchymal stem cells (MSCs) have been assessed for their
capacity to suppress inflammation and promote tissue repair. Regardless of whether the …