The secretion profile of mesenchymal stem cells and potential applications in treating human diseases
Y Han, J Yang, J Fang, Y Zhou, E Candi… - … and Targeted Therapy, 2022 - nature.com
Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …
A guide to assessing cellular senescence in vitro and in vivo
Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …
[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy
M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies
NC Noronha, A Mizukami, C Caliári-Oliveira… - Stem cell research & …, 2019 - Springer
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …
Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application
For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …
studied for their therapeutic potential across a wide range of diseases. In the preclinical …
Flow cytometry: principles, applications and recent advances
SM Manohar, P Shah, A Nair - Bioanalysis, 2021 - Taylor & Francis
Flow cytometry (FCM) is a sophisticated technique that works on the principle of light
scattering and fluorescence emission by the specific fluorescent probe-labeled cells as they …
scattering and fluorescence emission by the specific fluorescent probe-labeled cells as they …
Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO to promote immune privilege in the tumour microenvironment
Clinical response to immunotherapy is closely associated with the immunosuppressive
tumour microenvironment (TME), and influenced by the dynamic interaction between tumour …
tumour microenvironment (TME), and influenced by the dynamic interaction between tumour …
Human macrophage migration inhibitory factor potentiates mesenchymal stromal cell efficacy in a clinically relevant model of allergic asthma
IJ Hawthorne, H Dunbar, C Tunstead, T Schorpp… - Molecular Therapy, 2023 - cell.com
Current asthma therapies focus on reducing symptoms but fail to restore existing structural
damage. Mesenchymal stromal cell (MSC) administration can ameliorate airway …
damage. Mesenchymal stromal cell (MSC) administration can ameliorate airway …
Mesenchymal stromal cell therapeutic potency is dependent upon viability, route of delivery, and immune match
J Giri, J Galipeau - Blood advances, 2020 - ashpublications.org
Culture-adapted bone marrow mesenchymal stromal cells (MSCs) deploy paracrine anti-
inflammatory and tissue regenerative functionalities that can be harnessed as a living cell …
inflammatory and tissue regenerative functionalities that can be harnessed as a living cell …
The influence of hypoxia and IFN-γ on the proteome and metabolome of therapeutic mesenchymal stem cells
HM Wobma, MA Tamargo, S Goeta, LM Brown… - Biomaterials, 2018 - Elsevier
Over the past 15 years, mesenchymal stem cells (MSCs) have been assessed for their
capacity to suppress inflammation and promote tissue repair. Regardless of whether the …
capacity to suppress inflammation and promote tissue repair. Regardless of whether the …