Iron holds a central position at the host–pathogen interface because mammalian and
microbial cells have an essential demand for the metal, which is required for many metabolic …

Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …

A potent Th1 immune response is critical to the control of tuberculosis. The impact of an
additive Th2 response on the course of disease has so far been insufficiently characterized …

The seven Mycobacterium tuberculosis whiB-like genes encode small proteins postulated to
be transcriptional regulators. A systematic real-time reverse transcription-PCR analysis …

Bacteria transcriptional regulators are classified by their functional and sequence
similarities. Member of the TetR/AcrR family is two-domain proteins including an N-terminal …

During lung infection, Mycobacterium tuberculosis resides in macrophages and subverts the
bactericidal mechanisms of these professional phagocytes. Comprehension of this host …

Research over the past decade has advanced our understanding of the pathogenesis of
sarcoidosis and provided new insights into potential causes of this disease. It is important to …

Background Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects
approximately 2 billion people worldwide and is the leading cause of mortality due to …

Abstract Background The human pathogen Mycobacterium tuberculosis has the capacity to
escape eradication by professional phagocytes. During infection, M. tuberculosis resists the …

India already has earned the dubious distinction of being one of the countries with the
highest incidence of tuberculosis (TB). The conventional control measures have had little …