Ecology and genomics of Actinobacteria: new concepts for natural product discovery
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …
Extending the “one strain many compounds”(OSMAC) principle to marine microorganisms
Genomic data often highlights an inconsistency between the number of gene clusters
identified using bioinformatic approaches as potentially producing secondary metabolites …
identified using bioinformatic approaches as potentially producing secondary metabolites …
Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs
Methicillin-resistant Staphylococcus aureus (MRSA) pose a significant health threat as they
tend to cause severe infections in vulnerable populations and are difficult to treat due to a …
tend to cause severe infections in vulnerable populations and are difficult to treat due to a …
Marine bacteria as source of antimicrobial compounds
P Stincone, A Brandelli - Critical reviews in biotechnology, 2020 - Taylor & Francis
The marine environment encompasses a huge biological diversity and can be considered
as an underexplored location for prospecting bioactive molecules. In this review, the current …
as an underexplored location for prospecting bioactive molecules. In this review, the current …
Co-culture: stimulate the metabolic potential and explore the molecular diversity of natural products from microorganisms
Microbial secondary metabolites have long been considered as potential sources of lead
compounds for medicinal use due to their rich chemical diversity and extensive biological …
compounds for medicinal use due to their rich chemical diversity and extensive biological …
Natural products from actinomycetes associated with marine organisms
J Chen, L Xu, Y Zhou, B Han - Marine drugs, 2021 - mdpi.com
The actinomycetes have proven to be a rich source of bioactive secondary metabolites and
play a critical role in the development of pharmaceutical researches. With interactions of …
play a critical role in the development of pharmaceutical researches. With interactions of …
Enhancing chemical and biological diversity by co-cultivation
DM Selegato, I Castro-Gamboa - Frontiers in microbiology, 2023 - frontiersin.org
In natural product research, microbial metabolites have tremendous potential to provide new
therapeutic agents since extremely diverse chemical structures can be found in the nearly …
therapeutic agents since extremely diverse chemical structures can be found in the nearly …
Marine pharmacology in 2016–2017: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis and antiviral …
AMS Mayer, AJ Guerrero, AD Rodríguez… - Marine drugs, 2021 - mdpi.com
The review of the 2016–2017 marine pharmacology literature was prepared in a manner
similar as the 10 prior reviews of this series. Preclinical marine pharmacology research …
similar as the 10 prior reviews of this series. Preclinical marine pharmacology research …
New Metabolites From the Co-culture of Marine-Derived Actinomycete Streptomyces rochei MB037 and Fungus Rhinocladiella similis 35
Co-culture of different microbes simulating the natural state of microbial community may
produce potentially new compounds because of nutrition or space competition. To mine its …
produce potentially new compounds because of nutrition or space competition. To mine its …
Advances in microbial culturing conditions to activate silent biosynthetic gene clusters for novel metabolite production
HA Tomm, L Ucciferri, AC Ross - Journal of Industrial …, 2019 - academic.oup.com
Natural products (NPs) produced by bacteria and fungi are often used as therapeutic agents
due to their complex structures and wide range of bioactivities. Enzymes that build NPs are …
due to their complex structures and wide range of bioactivities. Enzymes that build NPs are …