Current therapies in clinical trials of Parkinson's disease: A 2021 update
Parkinson's disease (PD) is a progressive neurodegenerative disorder that currently has no
cure, but treatments are available to improve PD symptoms and maintain quality of life. In …
cure, but treatments are available to improve PD symptoms and maintain quality of life. In …
Data science, artificial intelligence, and machine learning: opportunities for laboratory medicine and the value of positive regulation
D Gruson, T Helleputte, P Rousseau, D Gruson - Clinical biochemistry, 2019 - Elsevier
Artificial intelligence (AI) and data science are rapidly developing in healthcare, as is their
translation into laboratory medicine. Our review article presents an overview of the data …
translation into laboratory medicine. Our review article presents an overview of the data …
Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v. 3.0
Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic
framework for integrative analysis of experimental molecular systems biology data and …
framework for integrative analysis of experimental molecular systems biology data and …
Personalized whole‐body models integrate metabolism, physiology, and the gut microbiome
Comprehensive molecular‐level models of human metabolism have been generated on a
cellular level. However, models of whole‐body metabolism have not been established as …
cellular level. However, models of whole‐body metabolism have not been established as …
Levodopa-induced dyskinesias in Parkinson's disease: An overview on pathophysiology, clinical manifestations, therapy management strategies and future directions
L di Biase, PM Pecoraro, SP Carbone… - Journal of clinical …, 2023 - mdpi.com
Since its first introduction, levodopa has become the cornerstone for the treatment of
Parkinson's disease and remains the leading therapeutic choice for motor control therapy so …
Parkinson's disease and remains the leading therapeutic choice for motor control therapy so …
Personalized metabolic whole-body models for newborns and infants predict growth and biomarkers of inherited metabolic diseases
E Zaunseder, U Mütze, JG Okun, GF Hoffmann… - Cell Metabolism, 2024 - cell.com
Comprehensive whole-body models (WBMs) accounting for organ-specific dynamics have
been developed to simulate adult metabolism, but such models do not exist for infants. Here …
been developed to simulate adult metabolism, but such models do not exist for infants. Here …
To restrict or not to restrict? Practical considerations for optimizing dietary protein interactions on levodopa absorption in Parkinson's disease
C Rusch, R Flanagan, H Suh, I Subramanian - npj Parkinson's Disease, 2023 - nature.com
Administration of levodopa for Parkinson's disease (PD) has remained the most effective
therapy for symptom management despite being in use for over 50 years. Advancing …
therapy for symptom management despite being in use for over 50 years. Advancing …
[HTML][HTML] Advances in flux balance analysis by integrating machine learning and mechanism-based models
The availability of multi-omics data sets and genome-scale metabolic models for various
organisms provide a platform for modeling and analyzing genotype-to-phenotype …
organisms provide a platform for modeling and analyzing genotype-to-phenotype …
Parkinson's disease patients' short chain fatty acids production capacity after in vitro fecal fiber fermentation
F Baert, C Matthys, J Maselyne, C Van Poucke… - npj Parkinson's …, 2021 - nature.com
Animal models indicate that butyrate might reduce motor symptoms in Parkinson's disease.
Some dietary fibers are butyrogenic, but in Parkinson's disease patients their butyrate …
Some dietary fibers are butyrogenic, but in Parkinson's disease patients their butyrate …
[HTML][HTML] Clinical implications of gastric complications on levodopa treatment in Parkinson's disease
Disorders of the gastrointestinal (GI) tract are common and distressing nonmotor symptoms
of Parkinson's disease (PD) that can adversely affect levodopa absorption and lead to OFF …
of Parkinson's disease (PD) that can adversely affect levodopa absorption and lead to OFF …