Glaucoma remains only partially understood, particularly at the level of intraocular pressure
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …

Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the
precise roles are not known. Understanding these complex processes, which may also be a …

With the combined purpose of facilitating useful vision over a lifetime, a number of ocular
cells have evolved specialized features not found elsewhere in the body. The trabecular …

Glaucoma is a blinding optic neuropathy, the main risk factor for which is increased
intraocular pressure (IOP). The trabecular meshwork, located within the iridocorneal angle …

The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …

Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …

Rationale: Corticosteroids (CSs) are the most effective asthma therapy, but responses are
heterogeneous and systemic CSs lead to long-term side effects. Therefore, an improved …

Glaucoma is a progressive and chronic neurodegenerative disorder characterized by
damage to the inner layers of the retina and deformation of the optic nerve head. The …

Alterations in stiffness of the trabecular meshwork (TM) may play an important role in primary
open-angle glaucoma (POAG), the second leading cause of blindness. Specifically, certain …