In tissue engineering and regenerative medicine, a biomaterial provides mechanical support
and biochemical signals to encourage cell attachment and modulate cell behaviour …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Discarded human donor organs have been shown to provide decellularized extracellular
matrix (dECM) scaffolds suitable for organ engineering. The quest for appropriate cell …

BACKGROUND To provide the optimal milieu for implantation and fetal development, the
female reproductive system must orchestrate uterine dynamics with the appropriate …

Based on the existing literature, a model is presented that postulates a “dynamic reciprocity”
between the extracellular matrix (ECM) on the one hand and the cytoskeleton and the …

Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a
significant challenge for the pharmaceutical and chemical industries. Generally …

This chapter looks at variables such as fibril diameter, orientation, tissue distribution, relative
concentrations and packing of fibrils into larger volumes, and search for patterns which …

Biomaterials based on seeding of cells on decellularized scaffolds have gained increasing
interest in the last few years and suggested to serve as an alternative approach to …

Importance of the field: Biomimetic scaffolds and substrates of extracellular matrices (ECMs)
play an important role in the regulation of cell function and in the guidance of new tissue …

Stem cells are a promising cell source for regenerative medicine. Stem cell differentiation
must be regulated for applications in regenerative medicine. Stem cells are surrounded by …