Complete and accurate DNA replication requires the progression of replication forks through
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …

The relationships between inflammation and cancer are varied and complex. An important
connection linking inflammation to cancer development is DNA damage. During …

The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …

Abstract 53BP1 is an enigmatic DNA damage response factor that gained prominence
because it determines the efficacy of PARP1 inhibitory drugs (PARPi) in BRCA1-deficient …

Summary Infection with CagA-producing Helicobacter pylori plays a causative role in the
development of gastric cancer. Upon delivery into gastric epithelial cells, CagA deregulates …

Chromosomal instability (CIN) is associated with many human diseases, including
neurodevelopmental or neurodegenerative conditions, age-related disorders and cancer …

Oncogene activation during tumorigenesis promotes DNA replication stress (RS), which
subsequently drives the formation of cancer-associated chromosomal rearrangements …

The protection of DNA replication forks under stress is essential for genome maintenance
and cancer suppression. One mechanism of fork protection involves an elevation in …

DNA replication and repair defects or genotoxic treatments trigger interferon (IFN)-mediated
inflammatory responses. However, whether and how IFN signaling in turn impacts the DNA …

Summary G-quadruplexes (G4s) form throughout the genome and influence important
cellular processes. Their deregulation can challenge DNA replication fork progression and …