When considering the control of gene expression, the focus has traditionally been on
transcriptional regulation. Recently, however, the large contribution made by mRNA decay …

Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively
degrades mRNAs harboring premature termination (nonsense) codons. If translated, these …

Studies of nonsense-mediated mRNA decay in mammalian cells have proffered unforeseen
insights into changes in mRNA–protein interactions throughout the lifetime of an mRNA …

The 5′ mRNA cap structure is essential for efficient gene expression from yeast to human. It
plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co …

Nonsense-mediated mRNA decay is a surveillance pathway that reduces errors in gene
expression by eliminating aberrant mRNAs that encode incomplete polypeptides. Recent …

Cells routinely make mistakes. Some mistakes are encoded by the genome and may
manifest as inherited or acquired diseases. Other mistakes occur because metabolic …

In eukaryotes, a specialized pathway of mRNA degradation termed nonsense-mediated
decay (NMD) functions in mRNA quality control by recognizing and degrading mRNAs with …

In eukaryotic cells, messenger RNAs harbouring premature termination codons (PTCs) are
rapidly degraded by a conserved post-transcriptional mechanism referred to as nonsense …

Endonuclease decay of nonsense-containing β-globin mRNA in erythroid cells generates
5′-truncated products that were reported previously to have a cap or caplike structure. We …

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades
mRNAs containing premature translation termination codons. In mammalian cells, a …