Radiochemistry for positron emission tomography

J Rong, A Haider, TE Jeppesen, L Josephson… - Nature …, 2023 - nature.com
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

Inverse electron demand Diels–Alder reactions in chemical biology

BL Oliveira, Z Guo, GJL Bernardes - Chemical Society Reviews, 2017 - pubs.rsc.org
The emerging inverse electron demand Diels–Alder (IEDDA) reaction stands out from other
bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and …

Applications of fluorine in medicinal chemistry

EP Gillis, KJ Eastman, MD Hill… - Journal of medicinal …, 2015 - ACS Publications
The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …

18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography

S Preshlock, M Tredwell, V Gouverneur - Chemical reviews, 2016 - ACS Publications
Diverse radiochemistry is an essential component of nuclear medicine; this includes
imaging techniques such as positron emission tomography (PET). As such, PET can track …

Chemistry for Positron Emission Tomography: Recent Advances in 11C‐, 18F‐, 13N‐, and 15O‐Labeling Reactions

X Deng, J Rong, L Wang, N Vasdev… - Angewandte Chemie …, 2019 - Wiley Online Library
Positron emission tomography (PET) is a molecular imaging technology that provides
quantitative information about function and metabolism in biological processes in vivo for …

Modern carbon–fluorine bond forming reactions for aryl fluoride synthesis

MG Campbell, T Ritter - Chemical Reviews, 2015 - ACS Publications
In recent years, there has been a dramatic increase in available methods for the installation
of fluorine and fluorine-containing functional groups in organic molecules, 1− 4 and the …

18F-Fluorination: Challenge and Opportunity for Organic Chemists

R Halder, T Ritter - The Journal of Organic Chemistry, 2021 - ACS Publications
18F-fluorination is an important and growing field in organic synthesis that has attracted
many chemists in the recent past. Here we present our own, biased perspective with a focus …

Fluorination of arylboronic esters enabled by bismuth redox catalysis

O Planas, F Wang, M Leutzsch, J Cornella - Science, 2020 - science.org
Bismuth catalysis has traditionally relied on the Lewis acidic properties of the element in a
fixed oxidation state. In this paper, we report a series of bismuth complexes that can undergo …

Fluorine-18 labelled building blocks for PET tracer synthesis

D Van Der Born, A Pees, AJ Poot, RVA Orru… - Chemical Society …, 2017 - pubs.rsc.org
Positron emission tomography (PET) is an important driver for present day healthcare.
Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview …

Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids

AV Mossine, AF Brooks, KJ Makaravage, JM Miller… - Organic …, 2015 - ACS Publications
A copper-mediated radiofluorination of aryl-and vinylboronic acids with K18F is described.
This method exhibits high functional group tolerance and is effective for the radiofluorination …