Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

Altered tissue mechanics and metabolism are defining characteristics of cancer that impact
not only proliferation but also migration. While migrating through a mechanically and …

Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

There is increasing evidence that skin aging is significantly enforced by the accumulation of
senescent dermal fibroblasts. Various stressors damaging macromolecules inside and …

Over the past decade, the study of metabolic abnormalities in cancer cells has risen
dramatically. Cancer cells can thrive in challenging environments, be it the hypoxic and …

Cell migration is crucial for cancer dissemination. We find that AMP-activated protein kinase
(AMPK) controls cell migration by acting as an adhesion sensing molecular hub. In 3 …

Energy deprivation is a frequent adverse event in tumors that is caused by mutations,
malperfusion, hypoxia, and nutrition deficit. The resulting bioenergetic stress leads to …

Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …

Cell migration during the invasion-metastasis cascade requires cancer cells to navigate a
spatially complex microenvironment that presents directional choices to migrating cells …

The need for improved prediction of clinical response is driving the development of cancer
models with enhanced physiological relevance. A new concept of 'precision biomaterials' is …