Advances in genome editing through control of DNA repair pathways
Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage.
Advancements in genome editing take advantage of these pathways to produce permanent …
Advancements in genome editing take advantage of these pathways to produce permanent …
Methods favoring homology-directed repair choice in response to CRISPR/Cas9 induced-double strand breaks
H Yang, S Ren, S Yu, H Pan, T Li, S Ge… - International journal of …, 2020 - mdpi.com
Precise gene editing is—or will soon be—in clinical use for several diseases, and more
applications are under development. The programmable nuclease Cas9, directed by a …
applications are under development. The programmable nuclease Cas9, directed by a …
Methodologies for improving HDR efficiency
M Liu, S Rehman, X Tang, K Gu, Q Fan, D Chen… - Frontiers in …, 2019 - frontiersin.org
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9
(Cas9) is a precise genome manipulating technology that can be programmed to induce …
(Cas9) is a precise genome manipulating technology that can be programmed to induce …
Emerging nanotechnology and advanced materials for cancer radiation therapy
Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal
radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However …
radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However …
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
JHL Fok, A Ramos-Montoya… - Nature …, 2019 - nature.com
DNA-dependent protein kinase (DNA-PK) is a critical player in the DNA damage response
(DDR) and instrumental in the non-homologous end-joining pathway (NHEJ) used to detect …
(DDR) and instrumental in the non-homologous end-joining pathway (NHEJ) used to detect …
[HTML][HTML] Mapping the genetic landscape of DNA double-strand break repair
Cells repair DNA double-strand breaks (DSBs) through a complex set of pathways critical for
maintaining genomic integrity. To systematically map these pathways, we developed a high …
maintaining genomic integrity. To systematically map these pathways, we developed a high …
DNA-PK as an emerging therapeutic target in cancer
IS Mohiuddin, MH Kang - Frontiers in oncology, 2019 - frontiersin.org
The DNA-dependent protein kinase (DNA-PK) plays an instrumental role in the overall
survival and proliferation of cells. As a member of the phosphatidylinositol 3-kinase-related …
survival and proliferation of cells. As a member of the phosphatidylinositol 3-kinase-related …
Clustered DNA double-strand breaks: biological effects and relevance to cancer radiotherapy
JA Nickoloff, N Sharma, L Taylor - Genes, 2020 - mdpi.com
Cells manage to survive, thrive, and divide with high accuracy despite the constant threat of
DNA damage. Cells have evolved with several systems that efficiently repair spontaneous …
DNA damage. Cells have evolved with several systems that efficiently repair spontaneous …
[HTML][HTML] Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer
G Borrego-Soto, R Ortiz-López… - Genetics and molecular …, 2015 - SciELO Brasil
Breast cancer is the most common malignancy in women. Radiotherapy is frequently used in
patients with breast cancer, but some patients may be more susceptible to ionizing radiation …
patients with breast cancer, but some patients may be more susceptible to ionizing radiation …
DNA damage foci: Meaning and significance
K Rothkamm, S Barnard, J Moquet… - Environmental and …, 2015 - Wiley Online Library
The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and
the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a …
the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a …