The main features that are commonly attributed to mitochondria consist of the regulation of
cell proliferation, ATP generation, cell death and metabolism. However, recent scientific …

The Th17/T-regulatory (Treg) cell imbalance is involved in the occurrence and development
of organ inflammation in systemic lupus erythematosus (SLE). Metabolic pathways can …

In this study we examined the metabolic requirements of human T helper cells and the effect
of manipulating metabolic pathways in Th17 and Treg cells. The Th17: Treg cell axis is …

Cancer metabolism is an essential aspect of tumorigenesis, as cancer cells have increased
energy requirements in comparison to normal cells. Thus, an enhanced metabolism is …

Metabolic fluxes involving fatty acid biosynthesis play essential roles in controlling the
differentiation of T helper 17 (TH17) cells. However, the exact enzymes and lipid metabolites …

Metformin, traditionally regarded as a hypoglycemic drug, has been studied in other various
fields including inflammation. The specific mechanism of metformin's effect on immune cells …

Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid
metabolism and the fatty acid lipidome in health and disease. A growing body of evidence …

Accumulating evidence indicates that metabolism reprogramming is critically important to T
cell differentiation, and manipulating metabolic pathways in T cells can shape their fate and …

Systemic lupus erythematosus (SLE) is a heterogeneous disease characterized by the
production of abnormal autoantibodies and immune complexes that can affect the organ and …

Multiple sclerosis (MS), as an autoimmune neurological disease with both genetic and
environmental contribution, still lacks effective treatment options among progressive …