The prevalence of obesity and atherosclerosis has substantially increased worldwide over
the past several decades. Peroxisome proliferator-activated receptors (PPARs), as fatty …

Herbal supplements are a significant source of drug-drug interactions (DDIs), herb-drug
interactions, and hepatotoxicity. Cytochrome P450 (CYP450) enzymes metabolize a large …

ABSTRACT Introduction: Pregnane X receptor (PXR) and the constitutive androstane
receptor (CAR) are two members of the nuclear receptor superfamily that play major roles in …

Structural and functional studies have provided numerous insights over the past years on
how members of the nuclear hormone receptor superfamily tightly regulate the expression of …

The nuclear receptor, constitutive androstane receptor (CAR), which forms a heterodimer
with the retinoid X receptor (RXR), was initially reported as a transcription factor that …

This reconnaissance study was undertaken to examine the occurrence of common
ultraviolet filters (UVF) and light stabilizers (UVLS), and preservatives in four different …

Xenobiotic agonists of constitutive androstane receptor (CAR) induce many hepatic drug
metabolizing enzymes, but following prolonged exposure, promote hepatocellular …

The constitutive androstane receptor (CAR) plays pivotal roles in drug-induced liver injury
through the transcriptional regulation of drug-metabolizing enzymes and transporters. Thus …

Numerous studies have demonstrated the correlation between human gut bacteria and host
physiology, mediated primarily via nuclear receptors (NRs). Despite this body of work, the …

Metabolic nuclear receptors are ligand-activated transcription factors which control a wide
range of metabolic processes and signaling pathways in response to nutrients and …