The excessive intake of alcohol is a serious public health problem, especially given the
severe damage provoked by chronic or prenatal exposure to alcohol that affects many …

Endogenous and exogenous neurotoxins are important factors leading to
neurodegenerative diseases. In the 1980s, the discovery that 1-methyl-4-phenyl-1, 2, 3, 6 …

Abstract Salsolinol (1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline) is a
tetrahydroisoquinoline derivative whose presence in humans was first detected in the urine …

Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) are prevalently co-
occurring, important risk factors for a broad array of neuropsychiatric diseases. To date, how …

After decades of uncertainties and drawbacks, the study on the role and significance of
acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the …

Abnormal consumption of ethanol, the ingredient responsible for alcoholic drinks' addictive
liability, causes millions of deaths yearly. Ethanol's addictive potential is triggered through …

The consumption of alcohol and caffeine affects the lives of billions of individuals worldwide.
Although recent evidence indicates that caffeine impairs the reinforcing properties of …

Salsolinol (1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline), a derivate of
dopamine, is suspected to be the most probable neurotoxin in the degeneration of …

Chronic ethanol intake results in brain oxidative stress and neuroinflammation, which have
been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present …

The increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder
(PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and …