The current case of quinolones: synthetic approaches and antibacterial activity
Quinolones are broad-spectrum synthetic antibacterial drugs first obtained during the
synthesis of chloroquine. Nalidixic acid, the prototype of quinolones, first became available …
synthesis of chloroquine. Nalidixic acid, the prototype of quinolones, first became available …
Synthetic and medicinal perspective of quinolines as antiviral agents
In current scenario, various heterocycles have come up exhibiting crucial role in various
medicinal agents which are valuable for mankind. Out of diverse range of heterocycle …
medicinal agents which are valuable for mankind. Out of diverse range of heterocycle …
Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore
J Deng, T Sanchez, LQ Al-Mawsawi, R Dayam… - Bioorganic & medicinal …, 2007 - Elsevier
Recently, we reported small-molecule chalcones as a novel class of HIV-1 integrase (IN)
inhibitors. The most potent compound showed an IC50 value of 2μM for both IN-mediated …
inhibitors. The most potent compound showed an IC50 value of 2μM for both IN-mediated …
Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure− activity relationship of a class of human immunodeficiency virus type 1 integrase …
S Pasquini, C Mugnaini, C Tintori, M Botta… - Journal of medicinal …, 2008 - ACS Publications
A set of 4-quinolone-3-carboxylic acids bearing different substituents on the condensed
benzene ring was designed and synthesized as potential HIV-1 integrase inhibitors …
benzene ring was designed and synthesized as potential HIV-1 integrase inhibitors …
Palladium-catalyzed tandem amination reaction for the synthesis of 4-quinolones
T Zhao, B Xu - Organic Letters, 2010 - ACS Publications
Palladium-Catalyzed Tandem Amination Reaction for the Synthesis of 4-Quinolones | Organic
Letters ACS ACS Publications C&EN CAS Find my institution Log In Organic Letters ACS …
Letters ACS ACS Publications C&EN CAS Find my institution Log In Organic Letters ACS …
The 4-quinolone-3-carboxylic acid motif as a multivalent scaffold in medicinal chemistry
C Mugnaini, S Pasquini, F Corelli - Current medicinal chemistry, 2009 - ingentaconnect.com
Quinolones are among the most common frameworks present in the bioactive molecules
and hence represent an attractive starting point for the design of combinatorial libraries …
and hence represent an attractive starting point for the design of combinatorial libraries …
Accounting for receptor flexibility and enhanced sampling methods in computer‐aided drug design
W Sinko, S Lindert… - Chemical biology & drug …, 2013 - Wiley Online Library
Protein flexibility plays a major role in biomolecular recognition. In many cases, it is not
obvious how molecular structure will change upon association with other molecules. In …
obvious how molecular structure will change upon association with other molecules. In …
Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance
M Lataillade, J Chiarella, MJ Kozal - 2007 - journals.sagepub.com
Background Two inhibitors of the HIV-1 integrase enzyme (INIs) are in late stage clinical
development. To date, approximately 42 mutations within the HIV-1 integrase (IN) gene …
development. To date, approximately 42 mutations within the HIV-1 integrase (IN) gene …
Cu2(OTf)2‐Catalyzed and Microwave‐Controlled Preparation of Tetrazoles from Nitriles and Organic Azides under Mild, Safe Conditions
L Bosch, J Vilarrasa - Angewandte Chemie International …, 2007 - Wiley Online Library
In connection with a project aimed at preparing new series of diketotetrazoles (see
compound 1 in Scheme 1, for which two representative tautomers are shown) and …
compound 1 in Scheme 1, for which two representative tautomers are shown) and …
Recent advances on dual inhibitors targeting HIV reverse transcriptase associated polymerase and ribonuclease H
JX Kang, GK Zhao, XM Yang, MX Huang… - European Journal of …, 2023 - Elsevier
Reverse transcriptase (RT) plays an indispensable role in the replication of human
immunodeficiency virus (HIV) through its associated polymerase and ribonuclease H …
immunodeficiency virus (HIV) through its associated polymerase and ribonuclease H …