Introduction Because of the high mortality of invasive fungal infections (IFIs), appropriate
exposure to antifungals appears to be crucial for therapeutic efficacy and safety. Materials …

ABSTRACT Introduction: Anti-Microbial Resistance (AMR) is a pandemic which threatens
modern medicine. There is a lack of effective drug treatment due to the slow pace, high cost …

The widespread use of antibiotics drives the evolution of antimicrobial-resistant bacteria
(ARB), threatening patients and healthcare professionals. Therefore, the development of …

Traditional methods employed to discover new antibiotics are both a time-consuming and
financially-taxing venture. This has led researchers to mine existing libraries of clinical …

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, which kills 1.8
million annually. Mtb RNA polymerase (RNAP) is the target of the first-line antituberculosis …

Drug-resistant bacterial pathogens pose an urgent public-health crisis. Here, we report the
discovery, from microbial-extract screening, of a nucleoside-analog inhibitor that inhibits …

Objectives Currently, only a few antibiotics are available to treat methicillin-resistant
Staphylococcus aureus (MRSA). One alternative approach includes adjuvants to antibiotic …

The treatment of Staphylococcus aureus (S. aureus) infections has become more difficult
due to the emergence of multidrug resistance in the bacteria. Here, we report the synthesis …

Fidaxomicin is an antibacterial drug in clinical use for treatment of Clostridium difficile
diarrhea. The active ingredient of fidaxomicin, lipiarmycin A3 (Lpm), functions by inhibiting …

Staphylococcus aureus (S. aureus) is the leading cause of a broad range of human
infections and associated with food poisoning worldwide. Nisin can be considered as a …