The production of induced pluripotent stem cells (iPSCs) represent a breakthrough in
regenerative medicine, providing new opportunities for understanding basic molecular …

For a long time, cardiovascular clinicians have focused their research on coronary
atherosclerotic cardiovascular disease and acute myocardial infarction due to their high …

Accumulating senescent cells within tissues contribute to the progression of aging and age-
related diseases. Botanical extracts, rich in phytoconstituents, present a useful resource for …

Cardiovascular diseases (CVD) can cause various conditions, including an increase in
reactive oxygen species (ROS) levels that can decrease nitric oxide (NO) availability and …

Rationale: Aging in the heart is a gradual process, involving continuous changes in
cardiovascular cells, including cardiomyocytes (CMs), namely cellular senescence. These …

Although a small number of cardiomyocytes may reenter the cell cycle after injury, the adult
mammalian heart is incapable of a robust cardiomyocyte proliferation. Periostin, a secreted …

Cardiac regenerative medicine faces big challenges such as a lack of adult cardiac stem
cells, low turnover of mature cardiomyocytes, and difficulty in therapeutic delivery to the …

A library of well-characterized human induced pluripotent stem cell (hiPSC) lines from
clinically healthy human subjects could serve as a useful resource of normal controls for in …

Many challenges remain in the preclinical evaluation, adjudication, and prioritization of
novel compounds in therapeutic discovery pipelines. These obstacles are evident by the …

Spinal cord injury (SCI) is a severe neurological disorder that causes neurological
impairment and disability. Neural stem/progenitor cells (NS/PCs) derived from induced …