It is increasingly important to accurately and comprehensively estimate the effects of
particular clinical treatments. Although randomization is the current gold standard …

Background In intervention trials, only randomization guarantees equal distributions of all
known and unknown patient characteristics between an intervention group and a control …

Importance No therapy has been shown to reduce the risk of serious adverse outcomes in
patients with nonalcoholic steatohepatitis (NASH). Objective To investigate the long-term …

Background Various observations have suggested that the course of COVID-19 might be
less favourable in patients with inflammatory rheumatic and musculoskeletal diseases …

Importance COVID-19 is a life-threatening illness for many patients. Prior studies have
established hematologic cancers as a risk factor associated with particularly poor outcomes …

Background Nirmatrelvir is a protease inhibitor with in-vitro activity against SARS-CoV-2,
and ritonavir-boosted nirmatrelvir can reduce the risk of progression to severe COVID-19 …

Background Previous atrial fibrillation screening trials have highlighted the need for more
targeted approaches. We did a pragmatic study to evaluate the effectiveness of an artificial …

Importance Within 2 decades of onset, 80% of untreated patients with relapsing-remitting
multiple sclerosis (MS) convert to a phase of irreversible disability accrual termed secondary …

Importance There has been limited research on patients with ST-segment elevation
myocardial infarction (STEMI) and COVID-19. Objective To compare characteristics …

Background: Exercise-based cardiac rehabilitation (CR) improves health-related quality of
life and exercise capacity in patients with heart failure (HF). However, CR efficacy in patients …