RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …

▪ Abstract Human leukemias are typified by acquired recurring chromosomal translocations.
Cloning of these translocation breakpoints has provided important insights into …

Core-binding factors (CBFs) are a class of haematopoietic transcription factors that are
crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation …

Embryonic development of multilineage hematopoiesis requires the precisely regulated
expression of lineage-specific transcription factors, including AML-1 (encoded by Runx1; …

We evaluated the frequency, genetic architecture, clinico-pathologic features and prognostic
impact of RUNX1 mutations in 2439 adult patients with newly-diagnosed acute myeloid …

There has been a remarkable explosion of knowledge into the molecular defects that
underlie the acute and chronic leukemias, leading to the introduction of targeted therapies …

Acute myeloid leukemia (AML) is a heterogeneous group of neoplastic disorders with great
variability in clinical course and response to therapy, as well as in the genetic and molecular …

The RUNX genes have come to prominence recently because of their roles as essential
regulators of cell fate in development and their paradoxical effects in cancer, in which they …

Analyses of 164 RUNX1 mutations (RUNX1 mut) in 147 of 449 patients (32.7%) with normal
karyotype or noncomplex chromosomal imbalances were performed. RUNX1 mut were most …

The AML1/CBFβ transcription factor complex, a frequent target of chromosomal
translocations in leukemia, is essential for the generation of definitive hematopoietic stem …