Transcription factor B-cell lymphoma/leukemia 11A (BCL11A) gene encodes a zinc-finger
protein that is predominantly expressed in brain and hematopoietic tissue. BCL11A …

The single base molecular substitution characterizing sickle cell haemoglobin, β 6 glu→ val,
might be expected to result in predictable haematological and clinical features. However, the …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Hemoglobinopathies though a monogenic disorder, show phenotypic variability. Hence,
understanding the genetics underlying the heritable sub-phenotypes of …

Sickle cell disease (SCD) is a complex genetic disorder associated with multiple clinical
manifestations, including increased susceptibility to bacterial and viral infections. This …

Sickle cell disease (SCD) is a severe hereditary blood disorder caused by a mutation of the
beta-globin gene, which results in a substantial reduction in life expectancy. Many studies …

Sickle cell anemia (SCA) is a severe disease characterized by anemia, acute clinical
complications, and a relatively short life span. In this disease, abnormal hemoglobin makes …

Abstract Introduction Fetal hemoglobin (HbF) is the major modifier for sickle cell disease
(SCD) severity. HbF is modulated mainly by three major quantitative trait loci (QTL) on …

Dear Editor, Sickle cell anaemia (SCA) is a monogenic disorder (β6-GAG-> GTG) with
exceptional phenotypic variability. In India, SCA is prevalent amongst tribal and some non …

Mendelian randomization (MR) is increasingly employed as a technique to assess the
causation of a risk factor on an outcome using observational data. The two-stage least …