Investigation of the complex relationships and dependencies of multiple cellular processes
that govern cardiac physiology and pathophysiology requires simultaneous dynamic …

The cardiovascular system adaptation occurs during pregnancy to ensure adequate
maternal circulation. Progesterone (P4) is widely used in hormone therapy to support …

Regional differences in ion channel activity in the heart control the sequence of
repolarization and may contribute to differences in contraction. Corticosteroids such as …

Ca2+ alternans (Ca-Alts) are alternating beat-to-beat changes in the amplitude of Ca2+
transients that frequently occur during tachycardia, ischemia, or hypothermia that can lead to …

The relationship between cardiac excitability and contractility depends on when Ca2+ influx
occurs during the ventricular action potential (AP). In mammals, it is accepted that Ca2+ …

Long after Trypanosoma cruzi infection, 40% of individuals develop a progressive chronic
chagasic cardiomyopathy (CCC), with systolic dysfunction and arrhythmias. Since we …

Previous studies have established that transmural gradients of the fast transient outward K+
current (I to, f) correlate with regional differences in action potential (AP) profile and …

This work aimed at testing the hypothesis that NOD/ShiLtJ mice (NOD) recapitulate the
cardiac disturbances observed on type 1 diabetes (T1D). NOD mice were studied 4 weeks …

Cardiac physiology of fish models is an emerging field given the ease of genome editing
and the development of transgenic models. Several studies have described the cardiac …

Background: Ryanodine receptor 2 (RyR2) is one of the first substrates undergoing
phosphorylation upon catecholaminergic stimulation. Yet, the role of RyR2 phosphorylation …