Reconstructing complex cancer evolutionary histories from multiple bulk DNA samples using Pairtree
Cancers are composed of genetically distinct subpopulations of malignant cells. DNA-
sequencing data can be used to determine the somatic point mutations specific to each …
sequencing data can be used to determine the somatic point mutations specific to each …
[HTML][HTML] Reconstructing cancer phylogenies using Pairtree, a clone tree reconstruction algorithm
Pairtree is a clone tree reconstruction algorithm that uses somatic point mutations to build
clone trees describing the evolutionary history of individual cancers. Using the Pairtree …
clone trees describing the evolutionary history of individual cancers. Using the Pairtree …
[HTML][HTML] Inferring cancer type-specific patterns of metastatic spread
D Koyyalagunta, K Ganesh, Q Morris - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
The metastatic spread of a cancer can be reconstructed from DNA sequencing of primary
and metastatic tumours, but doing so requires solving a challenging combinatorial …
and metastatic tumours, but doing so requires solving a challenging combinatorial …
[PDF][PDF] Pairtree: fast reconstruction of cancer evolutionary history using pairwise mutation relationships
Cancers are composed of multiple genetically distinct subpopulations of cancer cells. By
performing genome sequencing on tissue samples from a cancer, we can infer the existence …
performing genome sequencing on tissue samples from a cancer, we can infer the existence …
Reconstructing complex cancer evolutionary histories from multiple bulk DNA samples
J Wintersinger - 2021 - search.proquest.com
Cancers are composed of genetically distinct subpopulations of malignant cells. By
sequencing DNA from cancer tissue samples, we can characterize the somatic mutations …
sequencing DNA from cancer tissue samples, we can characterize the somatic mutations …