Simple Summary MMP9, due to its proteolytic activity, plays a key role in tumorigenesis by
regulating migration, epithelial-to-mesenchymal transition and survival of cancer cells …

Matrix metalloproteinases (MMPs) are zinc dependent proteolytic metalloenzyme. MMP-9 is
one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to …

Aortic aneurysms are a common vascular disease in Western populations that can involve
virtually any portion of the aorta. Abdominal aortic aneurysms are much more common than …

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …

Numerous studies have documented increases in matrix metalloproteinases (MMPs),
specifically MMP-9 levels following stroke, with such perturbations associated with …

Proteases are a set of enzymes that have been involved in multiple biological processes
throughout evolution. Among them, extracellular matrix (ECM) remodeling has emerged as …

Abnormal angiogenesis and vascular remodeling contribute to pathogenesis of a number of
disorders such as tumor, arthritis, atherosclerosis, restenosis, hypertension, and …

Matrix metalloproteinases (MMPs) are members of the metzincin group of proteases which
share the conserved zinc-binding motif in their catalytic active site. It was originally thought …

Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases
implicated in a variety of physiological and pathological processes. Over the decades …

Matrix metalloproteinases (MMPs) are a large family of enzymes that degrade the
extracellular matrix (ECM). Under pathologic conditions, overexpression of MMPs or …