There are four members of the EGFR family: EGFR, erbB2, erbB3 and erbB4. These
receptors form ligand-activated oligomers which regulate intracellular processes via an …

Lung cancer remains the leading cause of cancer-associated mortality worldwide, but with
the emergence of oncogene targeted therapies, treatment options have tremendously …

The molecular heterogeneity of cancer cells contributes to the often partial response to
targeted therapies and relapse of disease due to the escape of resistant cell populations …

The metastatic cascade is a complex and multistep process with many potential barriers.
Recent evidence has shown that microRNAs (miRNAs) are involved in carcinogenesis and …

Ability to grow under anchorage-independent conditions is one of the major hallmarks of
transformed cells. Key to this is the capacity of cells to suppress anoikis, or programmed cell …

The ERBB4 receptor tyrosine kinase promotes colonocyte survival. Herein, we tested
whether ERBB4's antiapoptotic signaling promotes transformation and colorectal …

ERBB4, one of four ErbB receptor tyrosine kinase family members, plays an important role in
the etiology and progression of lung cancer. In this study, we found that the ERBB4 protein …

Polypharmacology (action of drugs against multiple targets) represents a tempting avenue
for new drug development; unfortunately, methods capable of exploiting the known …

Background and aim: Gemcitabine, the first-line agent in pancreatic adenocarcinoma, has
shown limited clinical benefit. Cyclooxygenase-2 (COX-2) represent one of the most …

This invention relates to compositions and uses of NRG4, and to variants thereof and to
polynucleotides encoding NRG4, for therapeutic and diagnostic purposes, particularly …