Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in
the central nervous system (CNS); however, residual glutamate in the extracellular space is …

Glia form a central component of the nervous system whose varied activities sustain an
environment that is optimised for healthy development and neuronal function. Alpha-amino …

Objective Genetic loss of TSC1/TSC2 function in tuberous sclerosis complex (TSC) results in
overactivation of the mammalian target of rapamycin complex 1 pathway, leading to cellular …

Throughout the development of the cerebellar cortex, Purkinje neurones interact closely with
Bergmann glial cells, a specialized form of astrocyte. This review summarizes the intimate …

Glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system.
Once released, it binds to specific membrane receptors and transporters activating a wide …

Purkinje cells (PCs) present a unique cellular profile in both the cerebellum and the brain.
Because they represent the only output cell of the cerebellar cortex, they play a vital role in …

Glutamate is the predominant excitatory neurotransmitter in the mammalian CNS. It
mediates essentially all rapid excitatory signaling. Dysfunction of glutamatergic signaling …

This article reviews calcium signaling in three specialized types of glial cells: Müller cells of
the retina, Bergmann glial cells of the cerebellum, and radial glial cells of the developing …

Clinical studies on the role of the glutamatergic system in the pathogenesis of depression
found that ketamine induces an antidepressant response, but the molecular mechanisms …

The human brain is composed of nearly one hundred billion neurons and an equal number
of glial cells, including macroglia, ie, astrocytes and oligodendrocytes, and microglia, the …